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Cell Signaling in Cardiovascular Disease

About This Research Area

Cell regulation encompasses all the functions cells carry out to maintain homeostasis, in particular their responses to extracellular signals (hormones, neurotransmitters, etc.) and how cells transduce intracellular responses prompted by such signals. In addition to endogenous agents, many drugs and environmental agents use these same mechanisms to produce their most important effects. Understanding of cell signaling processes is fundamental to all areas of cardiovascular research. Numerous research opportunities exist within this program ranging from studies exploring new cell signaling mechanisms, to those examining aberrant signaling mechanisms associated with cardiovascular disease. Significantly, many of the recent breakthroughs in cardiovascular therapeutics result from basic studies on signaling molecules.

Research Faculty

Kelley Argraves, Ph.D.
Role of Sphingosine-1-Phosphate in Vasculogenesis and Angiogenesis

Scott W. Argraves, Ph.D.
Extracellular Matrix Biology

John Baatz, Ph.D.
Characterization of Hemoglobin and Surfactant Protein in Distal Airway Cells

Craig Beeson, Ph.D.
Regulation of Cardiac Bioenergetics during Stress Responses

Maria Buse, M.D., Ph.D.
Diabetes: Mechanisms of Insulin Resistance

James A. Cook, Ph.D.
Signal Transduction Pathways in Shock

Samar Hammad, Ph.D.
Sphingolipid Signaling Response to Modified Low-density Lipoprotein-Immune Complexes in Human Macrophages

Brett Harris, Ph.D.
The Development of the Atrio-ventricular Conduction System

Steven W. Kubalak, Ph.D.
Signaling Mechanisms Regulating Cardiac Remodeling

Dhandapani Kuppuswamy, Ph.D.
Growth and Protection of Hypertrophing Myocardium

Kyo Ho Lee, M.D., Ph.D.
Transcriptional Regulation in Cardiac Development

Louis Luttrell, M.D., Ph.D.
G Protein-coupled Receptor Signaling in the Cardiovascular System

Paul J. McDermott, Ph.D.
Translational Regulation of Cardiac Protein Synthesis

Donald R. Menick, Ph.D.
Regulation of Gene Expression in Cardiac Myocytes

Suniti Misra, Ph.D.
Role of Hyaluronan in Intimal Thickening in Congenital Birth Defect and Atherosclerosis

Terrence X. O'Brien, M.D.
Transcriptional Regulation of Specified Genes Involved in Cardiac Hypertrophy and the Development of the Conduction System

Rick Schnellmann, Ph.D.
Elucidation of Signaling Pathways of Cell Injury, Death and Regeneration

Steve Tomlinson, Ph.D.
The Complement System and Vascular Inflammation

Bryan Toole, Ph.D.
Functions of Hyaluronan and Emmprin in Oncogenic, Inflammatory and Atherosclerotic Signaling Pathways