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Mechanisms of Cardiovascular Development

About This Research Area

The area offers training and research in genetics and developmental biology, with investigators utilizing a variety of animal models to assess gene functions in embryonic development. Modern developmental genetics has become a central organizing field in all traditional disciples of biology, including cell biology, molecular biology, anatomy, evolution, and ecology. It has also contributed greatly to more practical fields such as medicine, environmental science and agriculture. The model systems studied by faculty members include Drosophila (fruit fly) for vascular system development, zebrafish for cardiac function and environmental impact on embryogenesis, chick for the formation of the cardiovascular system, mice for a variety of organogenesis studies, hematopoiesis, heart morphogenesis and human familial diseases for genetic linkage studies. In addition to transgenic and knockout technology, a variety of cell culture systems, including those for human stem cells, are utilized in the research.

Research Faculty

Christopher Drake, Ph.D.
Vasculogenesis

Brett Harris, Ph.D.
The Development of the Atrio-ventricular Conduction System

Amanda LaRue, Ph.D.
Hematopoietic Stem Cells in the Development and Progression of Solid Tumors

Kyo Ho Lee, M.D., Ph.D.
Transcriptional Regulation in Cardiac Development

Edward L. Krug, Ph.D.
Assessing the Anatomical Proteome of Heart Morphogenesis

Steven W. Kubalak, Ph.D.
Signaling Mechanisms Regulating Cardiac Remodeling

Roger R. Markwald, Ph.D.
Developmental Basis of Cardiovascular Disease

Terrence O'Brien, M.D.
Transcriptional Regulation of Specified Genes Involved in Cardiac Hypertrophy and the Development of the Conduction System

Arno Wessels, Ph.D.
Mechanisms of Cardiac Morphogenesis