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Advanced TMS Techniques for Mental Health and Disability – Combining TMS with EEG or fMRI or Both


Sponsored by the National Institute of Mental Health

Save the dates of April 25 through 27, 2019, for our new Advanced Research Intensive Workshop in collaboration with the National Institute of Mental Health: “Advanced TMS Techniques for Mental Health and Disability – Combining TMS with EEG or fMRI or Both." In addition to the in-person sessions, the meeting will be offered via videoconferencing over the Internet. More videoconference details to follow, so please apply to attend today.

The workshop is a three-day in-depth and hands-on look at advanced multimodal TMS techniques for mental health and disability research in order to increase the use of these tools to probe neural circuits and develop better neuromodulation approaches able to be tailored to individual patients. The workshop is created for well-trained mental health and rehabilitation researchers who would like to establish an independently funded laboratory using these tools.

The workshop includes daily lectures followed by hands-on experience in TMS-interleaved fMRI, methods for advanced TMS-EEG, and simultaneous TMS-EEG-fMRI. There will be international leaders with expertise in multimodal brain stimulation techniques speaking about these innovative and cutting-edge techniques.

Apply to attend now!

Scheduled speakers include:

Sven Bestmann, PhD
University College London, Professor
Dr. Sven Bestmann explores computational neurostimulation, action preparation and selection, value-based decisions and action costs, uncertainty, action and neuromodulators, reinforcement, motor learning and rehabilitation.

Michael R. Borich, P.T., D.P.T, PhD
Emory University Department of Rehabilitation Medicine, Assistant Professor
Dr. Michael Borich’s research utilizes multimodal neuroimaging and neurostimulation techniques to characterize the brain structural and functional correlates of neural plasticity associated with learning and experience.

Truman R. Brown, PhD
Medical University of South Carolina, Professor
Dr. Truman Brown has an interest in probing intracellular metabolism with MR and probing the metabolic status of tumors. He is leading research into developing new MR methodology to study human disease. He is also developing and testing a system for concurrent TMS-EEG-fMRI.

Amit Etkin, MD, PhD
Stanford University, Associate Professor of Psychiatry and Behavioral Sciences
Dr. Amit Etkin explores the neural basis of emotional disorders and their treatment, and how to leverage this knowledge to better understand how the brain works and to develop novel treatment interventions. He aims to establish a new intellectual, scientific and clinical paradigm for understanding and manipulating human brain circuits in healthy individuals and for treating psychiatric disease. He uses both concurrent TMS-EEG and TMS-fMRI toward these aims.

Matteo Fecchio, PhD
University of Milan Department of Biomedical and Clinical Sciences, Post-Doctoral Scholar
Dr. Fecchio uses TMS-EEG to investigate the neurological representation of consciousness in the brain. He currently uses TMS-EEG to calculate the perturbational complexity index (PCI) in varying states of consciousness and recently developed a toolbox for examining the quality of the TMS-EEG signal in real time.

Colleen A. Hanlon, PhD
Medical University of South Carolina, Associate Professor
Dr. Colleen Hanlon uses various techniques of brain stimulation and neuroimaging, including concurrent TMS-fMRI, to better understand and treat alcohol, cocaine, opiate, and nicotine addictions as well to examine how neuromodulation may assist stroke rehabilitation.

Marcello Massimini, MD, PhD
University of Milan Department of Biomedical and Clinical Sciences, Professor
Dr. Marcello Massimini explores EEG oscillations in cortical neurons during anesthesia and high-density EEG recordings in sleeping humans to describe the spatial-temporal dynamics of sleep slow oscillations. He is developing a novel technique (TMS and simultaneous hd-EEG) for studying cortico-cortical interactions from a perturbative perspective.

Manjari Narayan, PhD
Stanford University Department of Psychiatry, Postdoctoral Research Fellow
Dr. Manjari Narayan combines high dimensional statistics, graphical models, network science and statistical causal inference methods to analyze interventional neuroimaging experiments, including TMS-fMRI.

Alexander Opitz, PhD
University of Minnesota, Assistant Professor
Dr. Alexander Opitz’s focus is on the development of novel methods for non-invasive brain stimulation, including transcranial magnetic stimulation (TMS) and transcranial electric (TES) stimulation. He is particularly interested in the biophysical and physiological foundations of TMS and TES effects and how a better understanding of these can be translated into improved stimulation protocols in both research and clinical applications. He uses a combination of modeling, experimentation, and advanced data analysis techniques.

Paul Sajda, PhD
Columbia University, Professor of Biomedical Engineering, Electrical Engineering, and Radiology
Dr. Paul Sajda is using principles of reverse neuroengineering to characterize the cortical networks underlying perceptual and cognitive processes, such as rapid decision-making in the human brain. His laboratory pursues both basic and applied neuroscience research projects, with emphasis on non-invasive multi-modal neuroimaging, visual perception, brain-computer interfaces, application of machine learning to analysis of neural data and computational modeling of large neural systems.

Hartwig R. Siebner, MD, PhD
Copenhagen University Hospital Bispebjerg, Head of Research, Professor
Dr. Hartwig Siebner utilizes mapping and shaping causal dynamics in human brain networks, pathogenesis and pathophysiology of brain disorders, determinants of brain function and brain plasticity across the lifespan with particular focus on TMS-EEG.

Wei Wu, PhD
Stanford University, Instructor
Dr. Wu received the PhD degree in Biomedical Engineering from Tsinghua University, China, in 2012. From 2008 to 2010, he was a visiting student at the Neuroscience Statistics Laboratory, MIT, directed by Dr. Emery Brown. He is an associate editor of Neurocomputing and a member of IEEE Biomedical Signal Processing Technical Committee.

Christoph Zrenner, MD, PhD
University of Tübingen Center of Neurology, Post-Doctoral Scholar
Dr. Christoph Zrenner explores pharmacological modulation of TMS-evoked EEG responses, modulation of the cortical motor neuronal network through multi-coil-TMS, reorganization of cerebral networks in multiple sclerosis, and closed-loop-stimulation.

Ulf Ziemann, MD, PhD
University of Tübingen Center of Neurology, Professor of Neurology
Dr. Ulf Ziemann explores excitability, connectivity, plasticity and reorganization of motor circuits in health and disease at the systems level by using structural and functional MRI, MEG, EEG, transcranial magnetic and direct current stimulation (TMS, tDCS), near infrared spectroscopy (NIRS) and combinations of these techniques.

Apply to attend now!


(Draft agenda, subject to change)

Thursday, April 25, 2019 — Introduction to Perturbation-based imaging: Applications in rehabilitation and mental health research

Location: College of Health Professions (CHP) Building A, Room A-204

Talks will aim for 20 minutes with 10 minutes for questions. Each expert will present an overview of their program of work, specific to TMS-fMRI, TMS-EEG, or TMS-EEG-fMRI.

8:00 to 8:30 am Breakfast and registration

8:30 to 9:00 Colleen Hanlon, PhD

9:00 to 9:30 Ulf Ziemann, PhD

9:30 to 10:00 Amit Etkin, MD, PhD

10:00 to 10:15 Coffee Break

10:15 to 10:45 Sven Bestmann, PhD

10:45 to 11:15 Hartwig Siebner, PhD

11:15 to 11:45 Marcello Massimini, PhD

11:45 am to 12:45 pm Lunch

Location: CHP Building A, Atrium

12:45 to 1:00 Transition to Bioengineering Building, Room BEB-112

1:00 to 1:30 Michael Borich, PhD

1:30 to 2:00 Alexander Opitz, PhD

2:00 to 2:30 Paul Sajda, PhD

2:30 to 3:00 Discussion

3:00 to 3:15 Coffee Break

3:15 to 3:45 Prediction of stimulation areas: e-field modeling and targeting (Alexander Opitz, PhD)

3:45 to 4:15 Where to target TMS-fMRI-EEG in health and disease: Mapping integrity in functional and structural regions and networks (Amit Etkin, MD, PhD)

4:15 to 4:45 Targeting in TMS-fMRI: Virtual lesions, networking mapping, and performance (Sven Bestmann, PhD)

4:45 to 5:00 Questions, discussion, and closing

6:00 pm Social for attendees and speakers
Location: CHP Building A, Atrium


Friday, April 26, 2019

Location: College of Health Professions (CHP) Building A, Room 204

8:00 to 8:30 am Breakfast and registration

8:30 to 9:00 Equipment and Safety – Setting up TMS-fMRI at your institution (Truman Brown, PhD)

9:00 to 9:30 Hands on demonstration of e-field modeling (Alexander Opitz, PhD)

9:30 to 10:00 Stimulation Parameters: Impact of Pulse timing, coil angle, coil positioning (Alexander Opitz, PhD)

10:00 to 10:15 Coffee Break

10:15 to 10:45 Sham comparison and control sites in TMS-fMRI (Colleen Hanlon, PhD and Logan Dowdle)

10:45 to 11:15 Special considerations in MRI sequences and data processing/modeling: Specific examples at 2 institutions (Manjari Narayan, PhD and Logan Dowdle)

11:15 to 11:45 Artifact detection and reproducibility in TMS-fMRI: Specific examples (Logan Dowdle)

11:45 am to 12:45 pm Lunch

Location: College of Health Professions Building A, Atrium

12:45 to 1:00 Transition to BEB 112
Location: Bioengineering Building Room 112

1:00 to 1:30 Comparison of TMS-fMRI metrics: BOLD, functional connectivity, etc. (Manjari Narayan, PhD)

1:30 to 2:00 Questions, Discussion and walk to Center for Biomedical Imaging

2:00 to 4:00 Hands-on Demonstrations of TMS-fMRI Acquisition and Neuronavigation at the Center for Biomedical Imaging 3T Siemens Prisma (Logan Dowdle; Will Devries; Bashar Badran, PhD)

4:00 to 4:30 The basis of the TMS-EEG Signal: Measuring cortical excitability and more (Ulf Ziemann, PhD)

4:30 to 5:00 Non-transcranial evoked potential in TMS-EEG (Hartwig Siebner, PhD)

5:00 to 5:30 Questions, discussion, and closing


Saturday, April 27, 2019

Location: College of Health Professions (CHP) Building A, Room 204

8:00 to 8:30 Breakfast

8:30 to 9:00 TMS-EEG and TMS-EEG-fMRI Methodology: Physics, Safety, and Signal Processing (Paul Sajda, PhD)

9:00 to 9:30 Metrics in TMS-EEG: ERPs, PCI (Marcello Massimini, PhD)

9:30 to 10:00 Synchronizing TMS targeting with EEG (and fMRI) (Christoph Zrenner, PhD)

10:00 to 10:15 Coffee Break

10:15 to 10:45 Reproducibility in TMS-EEG (Christoph Zrenner, PhD)

10:45 to 11:15 Putting it all together: TMS-fMRI-EEG Metrics, Advantages, and Pitfalls (Paul Sajda, PhD; Truman Brown, PhD; and Mark George, MD)

11:15 to 11:45 Collecting genuine TMS-evoked potentials: A Graphical User Interface to control data quality in real-time (Matteo Fecchio, PhD)

11:45 am to 12:15 pm ARTIST: A fully automated artifact rejection algorithm for single-pulse TMS-EEG data (Wei Wu, PhD)

12:15 to 12:45 Preprocessing and identification of transcranially evoked and peripherally evoked potentials (Leo Tomasevic, PhD)

12:45 to 1:15 Controlling for Multiple Comparisons in TMS-EEG (Wei Wu, PhD)

1:15 to 2:00 Lunch

2:00 to 4:00 Hands on TMS-EEG and TMS-fMRI-EEG Demonstration in rotating groups (Paul Sajda, PhD; Truman Brown, PhD; Jayce Doose, MS; Matteo Fecchio, PhD; Wei Wu, PhD; Leo Tomasevic, PhD)

4:00 to 4:30 Machine Learning and Decoding Brain States in Perturbation-based Imaging (Paul Sajda, PhD)

4:30 to 5:00 The Next Frontier: The Future of Perturbation-based Imaging (Panel with all faculty)

5:00 pm Closing  


Apply to attend now!

Please save the dates April 25 through 27 and start planning to come to Charleston for this exciting workshop. To receive updates on this meeting and other NC NM4R offerings via email, please become a member of our Neuromodulation for Rehabilitation community.