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Publications & News

Systems Analysis of the Liver Transcriptome in Adult Male Zebrafish Exposed to the Plasticizer (2-Ethylhexyl) Phthalate (DEHP).Huff M, da Silveira WA, Carnevali O, Renaud L, Hardiman G. Sci Rep. 2018 Feb 1;8(1):2118. doi: 10.1038/s41598-018-20266-8.PMID:29391432

Effects of age on growth in Atlantic bluefin tuna (Thunnus thynnus).Api M, Bonfanti E, Lombardo F, Pignalosa P, Hardiman G, Carnevali O.Gen Comp Endocrinol. 2018 Jan 12. pii: S0016-6480(17)30718-9. doi: 10.1016/j.ygcen.2018.01.010. [Epub ahead of print] PMID:29339181

Semi-supervised identification of cancer subgroups using survival outcomes and overlapping grouping information.Wei W, Sun Z, da Silveira WA, Yu Z, Lawson A, Hardiman G, Kelemen LE, Chung D. Stat Methods Med Res. 2018 Jan 1:962280217752980. doi: 10.1177/0962280217752980. [Epub ahead of print] PMID:29336210

ShinyGPA: An interactive visualization toolkit for investigating pleiotropic architecture using GWAS datasets.Kortemeier E, Ramos PS, Hunt KJ, Kim HJ, Hardiman G, Chung D.PLoS One. 2018 Jan 8;13(1):e0190949. doi: 10.1371/journal.pone.0190949. eCollection 2018.PMID:29309429

CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response.Chatterjee S, Daenthanasanmak A, Chakraborty P, Wyatt MW, Dhar P, Selvam SP, Fu J, Zhang J, Nguyen H, Kang I, Toth K, Al-Homrani M, Husain M, Beeson G, Ball L, Helke K, Husain S, Garrett-Mayer E, Hardiman G, Mehrotra M, Nishimura MI, Beeson CC, Bupp MG, Wu J, Ogretmen B, Paulos CM, Rathmell J, Yu XZ, Mehrotra S.Cell Metab. 2018 Jan 9;27(1):85 to 100.e8. doi: 10.1016/j.cmet.2017.10.006. Epub 2017 Nov 9.PMID:29129787

SUMO Modification of the RNA-Binding Protein La Regulates Cell Proliferation and STAT3 Protein Stability.Kota V, Sommer G, Hazard ES, Hardiman G, Twiss JL, Heise T.Mol Cell Biol. 2017 Dec 29;38(2). pii: e00129-17. doi: 10.1128/MCB.00129-17. Print 2018 Jan 15.PMID:29084811

The Plasticizer Bisphenol A Perturbs the Hepatic Epigenome: A Systems Level Analysis of the miRNome.Renaud L, Silveira WAD, Hazard ES, Simpson J, Falcinelli S, Chung D, Carnevali O, Hardiman G.Genes (Basel). 2017 Oct 13;8(10). pii: E269. doi: 10.3390/genes8100269.PMID:29027980

Larval Red Drum (Sciaenops ocellatus) Sublethal Exposure to Weathered Deepwater Horizon Crude Oil: Developmental and Transcriptomic Consequences.Xu EG, Khursigara AJ, Magnuson J, Hazard ES, Hardiman G, Esbaugh AJ, Roberts AP, Schlenk D.Environ Sci Technol. 2017 Sep 5;51(17):10162 to 10172. doi: 10.1021/acs.est.7b02037. Epub 2017 Aug 18.PMID:28768411

Developmental transcriptomic analyses for mechanistic insights into critical pathways involved in embryogenesis of pelagic mahi-mahi (Coryphaena hippurus).Xu EG, Mager EM, Grosell M, Stieglitz JD, Hazard ES, Hardiman G, Schlenk D.PLoS One. 2017 Jul 10;12(7):e0180454. doi: 10.1371/journal.pone.0180454. eCollection 2017.PMID:28692652

Environmental perfluorooctane sulfonate exposure drives T cell activation in bottlenose dolphins.Soloff AC, Wolf BJ, White ND, Muir D, Courtney S, Hardiman G, Bossart GD, Fair PA.J Appl Toxicol. 2017 Sep;37(9):1108 to 1116. doi: 10.1002/jat.3465. Epub 2017 Apr 19.PMID:28425113

Novel transcriptome assembly and comparative toxicity pathway analysis in mahi-mahi (Coryphaena hippurus) embryos and larvae exposed to Deepwater Horizon oil. Xu EG, Mager EM, Grosell M, Hazard ES, Hardiman G, Schlenk D. Sci Rep. 2017 Mar 15;7:44546. doi: 10.1038/srep44546. PubMed PMID: 28295044; PubMed
Central PMCID: PMC5353654.

Genomics pipelines and data integration: challenges and opportunities in the research setting.Davis-Turak J, Courtney SM, Hazard ES, Glen WB Jr, da Silveira WA, Wesselman T, Harbin LP, Wolf BJ, Chung D, Hardiman G.Expert Rev Mol Diagn. 2017 Mar;17(3):225 to 237. doi: 10.1080/14737159.2017.1282822. Epub 2017 Jan 25. Review.PMID:28092471

Repression of caspase-3 and RNA-binding protein HuR cleavage by cyclooxygenase-2 promotes drug resistance in oral squamous cell carcinoma.Janakiraman H, House RP, Talwar S, Courtney SM, Hazard ES, Hardiman G, Mehrotra S, Howe PH, Gangaraju V, Palanisamy V.Oncogene. 2017 Jun 1;36(22):3137 to 3148. doi: 10.1038/onc.2016.451. Epub 2016 Dec 12.PMID:27941877

GPA-MDS: A Visualization Approach to Investigate Genetic Architecture among Phenotypes Using GWAS Results. Wei W, Ramos PS, Hunt KJ, Wolf BJ, Hardiman G, Chung D. Int J Genomics. 2016;2016:6589843. Epub 2016 Oct 27. PubMed PMID:27868058; PubMed Central PMCID: PMC5102874.

Clinical Application of a Modular Genomics Technique in Systemic Lupus Erythematosus: Progress towards Precision Medicine.Zollars E, Courtney SM, Wolf BJ, Allaire N, Ranger A, Hardiman G, Petri M.Int J Genomics. 2016;2016:7862962. doi: 10.1155/2016/7862962. Epub 2016 Aug 30.PMID:27656648

Time- and Oil-Dependent Transcriptomic and Physiological Responses to Deepwater Horizon Oil in Mahi-Mahi (Coryphaena hippurus) Embryos and Larvae. Xu EG, Mager EM, Grosell M, Pasparakis C, Schlenker LS, Stieglitz JD, Benetti D, Hazard ES, Courtney SM, Diamante G, Freitas J, Hardiman G, Schlenk D.Environ Sci Technol. 2016 Jul 19;50(14):7842 to 51. doi: 10.1021/acs.est.6b02205. Epub 2016 Jul 8. PMID: 27348429

Amplification of WHSC1L1 regulates expression and estrogen-independent activation of ERα in SUM-44 breast cancer cells and is associated with ERα over-expression in breast cancer. Irish JC, Mills JN, Turner-Ivey B, Wilson RC, Guest ST, Rutkovsky A, Dombkowski A, Kappler CS, Hardiman G, Ethier SP. Mol Oncol. 2016 Feb 27. pii: S1574-7891(16)00035-1. doi: 10.1016/j.molonc.2016.02.003. [Epub ahead of print] PMID: 27005559

Insulin receptor substrate 1 is a substrate of the Pim protein kinases. Song JH, Padi SK, Luevano LA, Minden MD, DeAngelo DJ, Hardiman G, Ball LE, Warfel NA, Kraft AS. Oncotarget. 2016 Mar 4. doi: 10.18632/oncotarget.7918. [Epub ahead of print] PMID: 26956053

Acute stress enhances the expression of neuroprotection- and neurogenesis-associated genes in the hippocampus of a mouse restraint model. Sannino G, Pasqualini L, Ricciardelli E, Montilla P, Soverchia L, Ruggeri B, Falcinelli S, Renzi A, Ludka C, Kirchner T, Grünewald TG, Ciccocioppo R, Ubaldi M, Hardiman G. Oncotarget. 2016 Feb 23;7(8):8455 to 65. doi: 10.18632/oncotarget.7225. PMID: 26863456

RNA-binding protein CELF1 promotes tumor growth and alters gene expression in oral squamous cell carcinoma. House RP, Talwar S, Hazard ES, Hill EG, Palanisamy V. Oncotarget. 2015 Dec 22;6(41):43620 to 34. doi: 10.18632/oncotarget.6204. PMID: 26498364

A post-developmental genetic screen for zebrafish models of inherited liver disease. Kim SH, Wu SY, Baek JI, Choi SY, Su Y, Flynn CR, Gamse JT, Ess KC, Hardiman G, Lipschutz JH, Abumrad NN, Rockey DC. PLoS One. 2015 May 7;10(5):e0125980. doi: 10.1371/journal.pone.0125980. eCollection 2015. PMID: 25950913

Oncogenic signaling in amphiregulin and EGFR-expressing PTEN-null human breast cancer. Kappler CS, Guest ST, Irish JC, Garrett-Mayer E, Kratche Z, Wilson RC, Ethier SP. Mol Oncol. 2015 Feb;9(2):527 to 43. doi: 10.1016/j.molonc.2014.10.006. Epub 2014 Oct 23. PMID: 25454348

Systems analysis of the prostate transcriptome in African-American men compared with European-American men. Hardiman G, Savage SJ, Hazard ES, Wilson RC, Courtney SM, Smith MT, Hollis BW, Halbert CH, Gattoni-Celli S. Pharmacogenomics. 2016 Jul;17(10):1129 to 1143.

News

Racial Disparities at Transcriptome Level Found For Prostate Cancer

Prostate Cancer Genes in African American Men May Be Affected by Vitamin D Supplementation

Weathered oil from DW Horizon spill may threaten fish embryos and larvae development Drs. Hazard, Courtney and Hardiman co-authors of a study on the Deep Horizon Spill