The Hollings Cancer Center (HCC) and SCTR have collaborated to provide a common infrastructure to manage and track bio-specimen information using TissueMetrix (TMX) software from Artificial Intelligence in Medicine, Inc.. In addition, it will enable the Holling's and SCTR sample collections to be linked with the rich laboratory, demographic, clinical and billing information available in the Clinical Data Warehouse. Finally, this solution enables other MUSC sample banks to use TissueMetrix.
This Biorepository system allows the collection of annotated biological specimens from various research protocols and routine care with appropriate IRB approval. Managed in TMX, the annotated specimen data is linked to clinical data from the MUSC Clinical Data Warehouse (CDW).
What is Available Today for Each Researcher?
The initial phase of the Biorepository system exposes the TissueMetrix data that is available in the MUSC CDW. This data is available for research queries through three services:
- The Hollings Cancer Center (HCC) Biorepository Honest Broker
- The Self-Service Biorepository Query
- The MUSC CDW Honest Broker
HCC Biorepository Honest Broker
This service allows the researcher to query against sample data stored in the Hollings Cancer Center biorepository collection. The patient-centric data supports queries on demographic information and sample types. Sample data available through this service is only available for those specimens contained in the HCC biorepository collection. Using this service is most beneficial when you are only looking at sample availability, with limited linked clinical information.
Biorepository & Research Pathology Services
Self-Service Biorepository Query
This online user interface allows users to query sample data with linked clinical data from patients who have willingly provided samples for research. The interface provides exploration of electronic medical data while protecting patient confidentiality and data security, in addition to providing sample availability. This interface provides information on samples available in the HCC collection, the SCTR collection, and other campus biorepository collections as they are added to TMX.
MUSC Clinical Data Warehouse for Research (CDW)
MUSC CDW Honest Broker
Researchers with IRB approved protocols that specifically request use or disclosure of PHI, or those who need more complex aggregate de-identified data than provided by the Self-Service Biorepository Query above, may request this information through the CDW Honest Broker service available through SPARC (SPARC application). Requests that include PHI will undergo a brief review by a Data Request Committee to assure compliance with the IRB approved protocol.
Process for identified data:
- Approved IRB protocol
- Official Data Request using SPARC *
- Data Request Committee oversight for release of data
- Data Released
* Note: A researcher may need aggregate results not available with the Self-Service Biorepository Query. For this case a complex query data request can be made with SPARC. IRB approval is not needed for an aggregate result complex query