Program Director and Prinical Investigator
Dr. Rockey joined MUSC in 2012 as Chair of the Department of Medicine. Previously, he was Division Chief of Liver and Digestive Diseases at UT-Southwestern in Dallas and, prior to that, Director of the multidisciplinary Duke Liver Center. Dr. Rockey is a physician-scientist with NIDDK funding for >25 years, including F32, K08, and R01 support since 1992. His basic research focuses on the liver as a model to study cell and molecular aspects of wound healing, including in vivomodels of liver injury, fibrogenesis and the hepatic wound healing response. Dr. Rockey also focuses on the molecular pathogenesis of portal hypertension, based on the postulate that portal hypertension is not only caused by fibrogenesis in the liver and thus is associated with typical structural changes, but that endothelial dysfunction specifically contributes to the increased intrahepatic resistance typical of most forms of portal hypertension.
Dr. Duncan joined MUSC in 2015 as Chair of the Department of Regenerative Medicine & Cell Biology. His research focuses on the use of mouse models and stem cells to understand the contribution of transcription factors toward embryonic development and diseases of the liver. His laboratory has used knockout mice and mouse embryonic stem cells to garner understanding of molecular pathways that control hepatogenesis and liver function during normal homeostasis as well as liver injury. More recently, Dr. Duncan’s laboratory has been using cells derived from human induced pluripotent stem cells (iPSCs) to study hepatocyte differentiation and to model and potentially treat metabolic liver disease. NIDDK has funded Dr. Duncan’s research continuously for >20 years, he has had leadership roles in several programmatic efforts, and he has published more than 100 original research manuscripts.