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Joseph Laboratory

Joseph

Brain, Cognition & Development

Our lab studies the neural basis of cognitive and affective behavior in typical and atypical development and, more recent, in neurodegeneration. We use fMRI to examine brain activation and connectivity across a wide spectrum of behaviors. A primary focus of the lab has been on the development of functional brain organization for face processing in both typically developing children and individuals with autism. We also have projects on personality risk for drug use in adolescents. I also work closely with collaborators from Psychiatry to study the impact of stress on functional brain organization in individuals with substance dependence. We have recently employed advanced approaches to characterize network topology and communication (graph-theory) and have been applying these analyses to the majority of our projects.

Our Team

Jane E. Joseph, Ph.D.
Professor Department of Neurosciences
Principal Investigator

Xun Zhu, Ph.D.
Postdoctoral Fellow

Brandon Vaughan
Graduate Student

Alumni and Past Employees

Joshua Swearigen
Graduate Student

Travis Nesland
I
nformation Resource Coordinator

Faraday Davies
Research Specialist

Michelle DiBartolo
Research Specialist

Publications

Journal Articles (Peer-Reviewed)

  • Willingham, D., Hollier, J., & Joseph, J. E. (1995). A Macintosh analogue of the rotary pursuit task. Behavior Research Methods, Instruments, & Computers, 27, 491-495.
  • Proffitt, D. R., Joseph, J. E., Bhalla, M., Bertamini, M., Durgin, F. H., Lynn, C., & Jernigan, J. D. (1995). External viewing of vehicle contents under varying tinting and illumination conditions. Transportation Research Record, 1485, 90-96.
  • Joseph, J. E., & Proffitt, D. R. (1996). Semantic versus perceptual influences of color in object recognition. Journal of Experimental Psychology: Learning, Memory and Cognition, 22, 407-429.
  • Joseph, J. E. (1997). Color processing in object verification. Acta Psychologica, 97, 95-127. (Invited paper)
  • Eden, G. F., Joseph, J. E., Brown, H. E., Brown, C. P., & Zeffiro, T. A. (1999). Utilizing hemodynamic delay and dispersion to detect fMRI signal change without auditory interference: The behavior interleaved gradients technique. Magnetic Resonance in Medicine, 41, 13-20.
  • Joseph, J. E., & Willingham, D. B. (2000). Effect of sex and joystick experience on pursuit tracking performance in adults. Journal of Motor Behavior, 32, 45-56.
  • Joseph, J. E. (2001). Functional Neuroimaging Studies of Category Specificity in Object Recognition: A Critical Review and Meta-Analysis. Cognitive, Affective and Behavioral Neuroscience, 1, 119-136.
  • Joseph, J. E., Noble, K., Eden, G. F. (2001). The neurobiological basis of reading. Journal of Learning Disabilities, 34,­ 566-579.
    Joseph, J. E., & Gathers, A. D. (2002). Natural and manufactured objects activate the “fusiform face area.” NeuroReport, 13(7), 935-938 (cover illustration). 
  • Joseph, J. E., Partin, D., & Jones, K. M. (2002). Hypothesis testing for selective, differential and conjoined brain activation. Journal of Neuroscience Methods, 118, 129-140. 
  • Joseph, J. E. & Gathers, A. D. (2003). Effects of structural similarity on neural substrates for object recognition. Cognitive, Affective and Behavioral Neuroscience, 3, 1-16.
  • Joseph, J. E., Gathers, A. D., & Piper, G. A. (2003). Shared and dissociated cortical regions for object and letter processing. Cognitive Brain Research, 17, 56-67.
  • Gathers, A. D., Bhatt, R., Corbly, C. R., Farley, A. B., Joseph, J. E. (2004). Developmental shifts in cortical loci for face and object recognition. NeuroReport, 15(10), 1549-1553.
  • Joseph, J. E., & Farley, A. B. (2004). Cortical regions associated with different aspects of performance in object recognition. Cognitive, Affective and Behavioral Neuroscience, 4(3), 364-378.
  • Bhatt, R. S, Hayden, A., Reed, A., Bertin, E., Joseph, J. E. (2006). Infants’ perception of information along object boundaries: Concavities versus convexities. Journal of Experimental Child Psychology, 94(2), 91-113.
  • Joseph, J. E., Cerullo, M. A., Farley, A. B., Steinmetz, N. A., Mier, C. R. (2006). fMRI correlates of  cortical specialization and generalization for letter processing. NeuroImage, 32, 806-820.
  • Joseph, J. E., Powell, D. K., Anderson, A. H., Bhatt, R. A., Dunlap, M., Foldes, S., Forman, E., Hardy,  P. A., Steinmetz, N. A., Zhang, Z. (2006). fMRI in Alert, Behaving Monkeys: An Adaptation of the Human  Infant  Familiarization Novelty Preference Procedure. Journal of Neuroscience Methods, 157(1), 10-24.
  • Liu, X., Wang, H., Corbly, C. R., Zhang, J., Joseph, J. E. (2006). An fMRI study of the numerical stroop effect in a two-digit number comparison task. Journal of Cognitive Neuroscience, 18(9), 1518-1530.
  • Joseph, J. E., Gathers, A. D., Liu, X., Corbly, C. R., Whitaker, S. K., & Bhatt, R. S. (2006). Neural developmental changes in processing inverted faces. Cognitive, Affective and Behavioral Neuroscience, 6(3), 223-235.
  • Hayden, A., Bhatt, R. S., Joseph, J. E., Tanaka, J. W. (in press). The other-race effect in infancy: Evidence using a morphing technique. Infancy.
  • Hayden, A., Reed, A., Joseph, J. E., & Bhatt, R. S. (2007). The development of expert face processing: Are infants sensitive to normal differences in second-order relational information? Journal of Experimental Child Psychology, 97, 85-98.
  • Liu, X., Powell, D. K., Wang, H., Gold, B. T., Corbly, C. R., & Joseph, J. E. (2007). Functional dissociation in frontal and striatal areas for processing positive and negative reward information. Journal of Neuroscience, 27(17), 4587- 4597.
  • Martin, S. B., Covell, D. J., Joseph, J. E., Chebrolu, H., Smith, C. D., Kelly, T. H., & Gold, R. T. (2007). The Human Right Anterior Hippocampus is Larger in Experience-Seekers. Neuropsychologia, 45, 2874-2881.
  • Liu, X., Steinmetz, N. A., Farley, A. B. Smith, C. D., & Joseph, J. E. (2008). Mid-fusiform activation during object discrimination reflects the process of differentiating structural descriptions. Journal of Cognitive Neuroscience, 20 (9), 1-16.
  • Joseph, J. E., Liu, X., Jiang, Y., Lynam, D. & Kelly, T. H. (2008). Neural correlates of emotional reactivity in sensation seeking, Psychological Science, 20 (2), 215-223.
  • Jiang, Y., Lianekhammy, J., Lawson, A. L., Guo, C., Lynam, D., Joseph, J. E., Gold, B. T., & Kelly, T. H. (in press). Brain adaptation to repeated exposure of visual stimuli predicts self-reported boredom susceptibility. Psychiatry Research: Neuroimaging.
  • Bhatt, R. S., Hayden, A., Kangas, A., Zieber, N, & Joseph, J. E. (in press). Part perception in
  • infancy: Sensitivity to the short-cut rule. Attention, Perception, & Psychophysics.
  • Joseph, J. E., Gathers, A. D., & Bhatt, R. (in press). Progressive and regressive developmental changes in neural substrates for face processing: Testing specific predictions of the Interactive Specialization account. Developmental Science.

 Book Chapters & Commentaries

  • Joseph, J. E. (2002). Preface to the special section on functional magnetic resonance imaging methods. Journal of Neuroscience Methods
  • Cerullo, M. A., Farley, A. B., Mier, C. M., Steinmetz, N. A. & Joseph, J. E. (2006). Are word and letter processing regions modular? An operational definition using fMRI. In F. J. Chen (Ed.). Brain Mapping and Language. Hauppauge, NY: Nova Science Publishers, Inc.
  • Joseph, J. E., Powell, C. A., Johnson, N. F., & Kedia, G. (2008). The functional neuroanatomy of envy. In R. Smith (Ed.), Envy: Theory and Research. New York: Oxford University Press, Inc.
  • Pushkarskaya, H., Smithson, M., Liu, X., & Joseph, J. E. (submitted). Neuroeconomics of Environmental Uncertainty and the Theory of Firm. To appear in M. Day, A. Stanton, & I. Welpe (Eds.). Neuroeconomics and the Firm.

Technical Reports

  • Proffitt, D. R., Bertamini, M., Bhalla, M., & Joseph, J. E. (1996). The effect of reduced transmittance window tinting on drivers’ ability to detect targets in their rear-view mirrors: Final report. Virginia Transportation Research Council.
  • Proffitt, D. R., Joseph, J. E., Bhalla, M., & Bertamini, M. (1994). The influence of window tinting and auxiliary lighting on nighttime viewing of vehicle contents: A report to the governor and general assembly in response to Senate Joint Resolution 293, 1993 session. Virginia Transportation Research Council.
  • Proffitt, D. R., Joseph, J. E., Bhalla, M., & Durgin, F. H. (1994). External viewing of vehicle contents under varying tinting and illumination conditions: A report to the governor and general assembly in response to Senate Joint Resolution 293, 1993 session. Virginia Transportation Research Council.

Published Abstracts

  • Goettl, B. P., & Joseph, J. E. (1990).  Central processing load, response demands and tracking strategies [Abstract]. Proceedings of the Human Factors Society 34th Annual Meeting, 2, 1504-1508.
  • Goettl, B. P., & Joseph, J. E. (1991).  Performance feedback and the optimum-maximum procedure [Abstract]. Proceedings of the Human Factors Society 35th Annual Meeting, 2, 1486-1490.
  • Joseph, J. E. (1997).  An advantage for color photographs in face and object discrimination [Abstract]. Journal of Cognitive Neuroscience: Supplement, 78.
  • Eden, G. F., Joseph, J. E., Brown, H. E., Brown, C. P., & Zeffiro, T. A. (1998). fMRI acquisition without auditory interference: The “Flatcar” design [Abstract]. NeuroImage, 7(4), S538.
  • Joseph, J. E., Zeffiro, T. A., & Eden, G. E. (1998). Radial visual motion processing in posterior parietal cortex [Abstract]. NeuroImage, 7(4), S328.
  • Joseph, J. E., Zeffiro, T. A., Berger, J., & Eden, G. F. (1999). Functional neuroanatomy of phonological processing [Abstract]. Journal of Cognitive Neuroscience: Supplement, 53.
  • Eden, G. F., Joseph, J. E., Jones, K., Berger, J., & Zeffiro, T. A. (1999). Functional neuroanatomy of phonological processing: Visual versus auditory stimuli [Abstract]. NeuroImage, 9(6), S1055.
  • Zeffiro, T. A., Joseph, J. E., Wang, J., Woods, R., &  Eden, G. F. (1999). Head motion correction optimization for fMRI [Abstract]. NeuroImage, 9 (6), S100.
  • Joseph, J. E., Eden, G. F., Jones, K., & Zeffiro, T. A. (1999). Co-localization of visual motion and phonological processing in lateral extrastriate cortex [Abstract]. Society for Neuroscience Abstracts, 25, Part II, 1813.
  • Joseph, J. E., Gareau, L., & Eden, G. (2000). Implicit temporal sequence learning during a rapid naming task [Abstract]. Journal of Cognitive Neuroscience: Supplement, 131.
  • Eden, G., Jones, K., Zeffiro, T., & Joseph, J. E. (2000). A functional magnetic resonance imaging study of naming and articulation rate. Journal of Cognitive Neuroscience: Supplement, 116.
  • Joseph, J. E., Jones, K. M., Zeffiro, T. A., & Eden, G. F. (2000). fMRI correlates of structural similarity in object naming [Abstract]. Society for Neuroscience Abstracts, 26, Part II, 1502.
  • Joseph, J. E. & Piper, G. A. (2001). Parametric variation of structural similarity in object recognition [Abstract]. Journal of Cognitive Neuroscience: Supplement, 134.
  • Gathers, A. D., Piper, G., Partin, D., & Joseph, J. E. (2001). Prefrontal and parietal involvement in a structurally graded object recognition task [Abstract]. Society for Neuroscience Abstracts, 27, Program No. 849.14.
  • Gathers, A. D. & Joseph, J. E. (2002). FMRI study reveals face processing overlaps with areas involved in shape processing [Abstract]. Journal of Cognitive Neuroscience: Supplement, 46.
  • Joseph, J. E. & Gathers, A. D. (2002). fMRI evidence against cortical specialization in the fusiform gyrus for letter and face recognition [Abstract]. Society for Neuroscience Abstracts, 28, Program No. 161.7.
  • Joseph, J. E., Dilks, S. K. & Harris Wright, H. (2003). Modulation of fMRI response by priming effects during strategic lexical decision [Abstract]. Journal of Cognitive Neuroscience: Supplement, 30.
  • Joseph, J. E. & Steinmetz, N. A. (2003). Resolving Color and Shape Similarity in the Human Ventral Processing [Abstract].
  • Gathers, A. D. & Joseph, J. E. (2003). An investigation of the functional neural correlates of object and face recognition in children. NeuroImage, 19 (2).
  • Gathers, A. D. & Joseph, J. E. (2003). A comparison of visual shape processing in children and adults using fMRI. Society for Neuroscience Abstracts, 29, Program No. 819.10.
  • Gathers, A., Bhatt, R., & Joseph, J. E. (2004). Face and object processing across development: A Structural similarity mechanism. Journal of Cognitive Neuroscience: Supplement, 126.
  • Farley, A. & Joseph, J. E. (2004). Performance-related cortical activation patterns in object recognition tasks. Journal of Cognitive Neuroscience: Supplement, 186.
  • Joseph, J. E., Steinmetz, N., & Farley, A. (2004). Letter-selective activation in left inferior parietal cortex depends on linguistic but not perceptual processing. Journal of Cognitive Neuroscience: Supplement, 186.
  • Gathers, A.D., Bhatt, R. S., Corbly, C. R., Farley, A. B., Joseph, J. E. (2004). A developmental fMRI investigation of the neural correlates of object and face recognition. NeuroImage, 22 (Supplement 1), e971-e972.
  • Cerullo, M. A., Mier, C. R. & Joseph, J. E.. (2004). Testing the modularity of cognitive domains with functional magnetic resonance imaging. Program No. 664.11. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. Online.
  • Corbly, C. R., Blonder, L. X., Curry, T. B., Farley, A. B., Gathers, A. D., Kelly, T. H., Liu, X., & Joseph, J. E. (2004). Are brain activation patterns associated with spatial cognition affected by menstrual cycle? An fMRI study. Program No. 81.14. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. Online.
  • Gathers, A. D., Bhatt, R., Corbly, C. R., Liu, X., & Joseph, J. E. (2004). Developmental changes in neural correlates for upright and inverted faces. Program No. 481.10. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. Online.
  • Joseph, J. E., Liu, X., & Farley, A. B. (2004). Effect of perceptual and structural similarity on ventral temporal cortex activation in an object matching task. Program No. 713.13. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. Online.
  • Joseph, J. E., Powell, D. K., Andersen, A. H., Bhatt, R. S., Dunlap, M. K., Foldes, S. T., Forman, E., Hardy, P. A., Steinmetz, N. A., Zhang, Z. (2005). fMRI of novelty detection in alert, behaviorally naïve Rhesus monkeys Journal of Cognitive Neuroscience: Supplement, 104.
  • Liu, X., Corbly, C., Whitaker, S. & Joseph, J. E. (2005). Involvement of the ventral temporal cortex in object matching depends on structural descriptions but not on visual similarity. NeuroImage, 26 (Supplement 1): 24.
  • Liu, X., Corbly, C., & Joseph, J. E. (2005). Involvement of the ventral temporal cortex in the object matching depends on structural descriptions and similarity of the stimuli. Journal of Cognitive Neuroscience: Supplement, 104.
  • Gold B.T., Balota D.A., Jones S.J., Joseph J.E., Powell D.K., Smith C.D., & Andersen A.H.. Neural correlates of automatic and controlled semantic priming. Human Brain Mapping Conference. Toronto, Canada, June, 2005. NeuroImage, 26 (Supplement 1): 49.
  • Joseph, J. E., Powell, D. K., Andersen, A. H., Bhatt, R. S., Dunlap, M. K., Foldes, S. T., Forman, E., Hardy, P. A., Steinmetz, N. A., Zhang, Z. (2005). fMRI adaptation in freely viewing monkeys correlates with behavioral adaptation. Program No.66.11. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. Online.
  • Liu, X., Corbly, C.R., & Joseph, J.E. (2006). To bet or not to bet, that is the question. Poster presented at the 13th Annual Meeting of Cognitive Neuroscience Society, San Francisco, CA.
  • Johnson, N. F., Richardson, A. D.  &  Brueckner, J. K. (2007) Department of Anatomy and Neurobiology, University of Kentucky, KY. A novel use of podcasting in teaching cross-sectional anatomy.  The 24th Annual Meeting of the American Association of Clinical Anatomists Platform Presentation.
  • Richardson, A. D., Johnson, N. F., & Brueckner, J. K. (2007) Department of Anatomy and Neurobiology, University of Kentucky, KY.  Evaluation of podcasting as a learning tool for independent study of cross-sectional anatomy.  The 24th Annual Meeting of the American Association of Clinical Anatomists, 2007.  *Recipient of the Sandy C. Marks, Jr. Student Poster Presentation Award
  • Johnson N, Boyce D., Brosky T. (2005) Is VAX-D an effective treatment for LBP? A Systematic Review of the Literature. American Physical Therapy Association Combined Sections Meeting, New Orleans.
  • Joseph, J. E., Dekhtyar, O., Liu, X., Corbly, C. R., Gathers, A. D., & Bhatt, R. S. (2007) Functional brain development for face recognition involves a reduction in redundant pathways: Evidence from functional connectivity analyses.  Program No.866.8. 2007 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. Online.
  • Clark, J. D., Dekhtyar, O., Liu, X., Corbly, C. R., Bhatt, R. S., & Joseph, J. E. (2008) Developmental changes in functional connectivity for object processing in the adult face-processing network
  • Clark, J. D., Dekhtyar, O., Liu, X., Gathers, A. D., Corbly, C. R., Bhatt, R. S., & Joseph, J. E. (2008) Emergence of right frontal connections for face processing across development: comparisons with object processing connectivity
  • Johnson, N. F., Richardson, A. D., & Brueckner, J. K. (2008) Online learning: bringing the teacher to the student using Camtasia Studio software
  • Johnson, N. F., Powell, D. K., Anderson, A. H., Bhatt, R. S., Bryant, R., Dunlap, M. K., Foldes, S. T., Forman, E., Hardy P. A., Steinmetz, N. A., Corbly, C. R., Zhang, Z., & Joseph, J. E. (2008) fMRI adaptation and change detection in the naive non-human primate
  • Johnson, N. F., Powell, D. K., Anderson, A. H., Bhatt, R. S., Bryant, R., Dunlap, M. K., Foldes, S. T., Forman, E., Hardy P. A., Steinmetz, N. A., Corbly, C. R., Zhang, Z., & Joseph, J. E. (2008) Novelty and adaptation associated regions in the naive non-human primate: an fMRI study
  • Corbly, C. R., Al-Alem, L., Liu, X., Kelly, T., Curry, T., Joseph, J. E., (2008) Effect of sex and menstrual cycle on brain activation for 3D mental rotation
  • Joseph, J. E., Corbly, C. R., Al-Alem, L., Epperly, G., Liu, X., Curry, T., Kelly, T., (2008) Effect of sex and menstrual cycle on brain activation for verbal working memory
  • Clark, J. D., Dekhtyar, O., Liu, X., Corbly, C. R., Bhatt, R., Joseph, J. E. (2008) Developmental Functional Connectivity of Manufactured Objects in the Adult Face-Processing Network
  • Clark, J. D.,  Dekhtyar, O., Liu, X., Gathers, A. D., Corbly, C. R., Bhatt, R., Joseph, J. E (2008) Emergence of right frontal connections for face processing across development: comparisons with object processing connectivity.

Popular Press

  • Popular Science (J. R. Callihan, W. G. Phillips), Hear this (or try to), February, 2002, Vol. 260, Issue 2.
  • Odyssey (A. Gregory), Reshaping Women’s Health Research, Summer, 2006.
  • US News & World Report, Thrill-Seekers' Brains May Be Wired Differently, February 19, 2009.
  • Dana Foundation (B. Patoine), Desperately Seeking Sensation: Fear, Reward, and the Human Need for Novelty, October 13, 2009.

Links

Desperately Seeking Sensation: Fear, Reward, & the Human Need for Novelty

Neuroscience Begins to Shine Light on the Neural Basis of Sensation-Seeking.
Why are some people drawn to intense, even fear-inducing thrills while others shun the mere thought? How is it that the same horror movie can be entertainment to one person and tension-filled torture to another? Is something different going on in the brains of these people?   

The Guide for Getting Risky

 Although the term “risky behavior” may elicit images of skydivers or rogue stock traders, we all weigh certain risks and rewards before initiating a plan of action. And all things being equal, we’re usually willing to risk some sort of consequence if the potential payoff is great enough. 

Risk is in the Brain of the Beholder

The past several decades of research into human brains have included deep looks at how people deal with risk. Scientists say they have discovered neural pathways, maps of the mind, that seem to correlate with the kinds of people who deal well with, more particularly, financial risk.