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Darby Children’s Research Institute Pediatric Research Symposium


Please join us on Friday, April 12, 2019, 8 am - 4:30 pm!

This year's primary theme: Progress in Pediatric Kidney Transplants

Registration is open!

MUSC Bioengineering Building, 1st Floor, Room 110

Abstracts, Posters, Judging event and Award Ceremony

A senior faculty member from the research team should be present for the platform presentation. 

The Awards will include:

  • Outstanding Research Poster by a Trainee $300
  • Outstanding Research Poster by a Faculty Member $300
  • Outstanding Oral Presentation by a Trainee $500
  • Outstanding Oral Presentation by a Faulty Member $500
  • The Mitchell Rubin Award for Pediatric Research (Senior Faculty) $500
  • The Mitchell Rubin Award for Pediatric Research (Junior Faculty) $500

Keynote Presentation: 

Friday, April 12, 2019, 8 a.m. - 9 a.m.

headshot of Dr. Prasad Deverajan

Prasad Devarajan, MD FAAP

Louise M Williams Endowed Chair, Professor of Pediatrics and Developmental Biology
Director of Nephrology and Hypertension
Cincinnati Children’s Hospital Medical Center
University of Cincinnati College of Medicine

"Biomarkers of Acute Kidney Injury: From Serendipity to Utility"

Presentation Summary: The incidence of acute kidney injury (AKI) is alarmingly high and rising globally, but still lacks awareness.  Recent large international epidemiologic studies have revealed an incidence of 30% among critically ill infants and children.  AKI has serious short-term complications – more than 10% of critically ill infants and children with AKI die due to complications from renal failure.  AKI also has serious long-term consequences, and has been strongly associated with the development of hypertension and chronic kidney disease.  Our current diagnosis and management of AKI is seriously hampered by the delay in diagnosis due to the use of serum creatinine, an insensitive and non-specific metabolite that merely reflects renal function in the steady state.  Fortunately, recent unbiased gene and protein expression analyses have identified a number of novel pathways and biomarkers that are being translated and validated for clinical use. This presentation will provide an update on the recent epidemiologic studies of AKI in children.  We will review the limitations of serum creatinine in the current detection of AKI.  We will then focus on the discovery, translation, and current clinical status of novel non-invasive biomarkers for the prediction, differential diagnosis, and prognosis of AKI.