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  • Repeated alcohol detoxifications can lead to an increase in seizure risk.
  • Use of benzodiazepines for multiple withdrawals is associated with increased drinking.
  • Outpatient alcohol withdrawal can be accomplished more safely with anticonvulsant medications.
  • Developed clinical laboratory procedures for evaluating pharmacotherapeutic effects on indices of craving and motivation to drink.
  • Brains of alcoholics react to alcohol cues differently from social drinkers and medications can block that reaction.
  • Established widely-used mouse model of alcohol dependencies and relapse drinking.
  • Showed that alcohol directly disrupts neutral network patterns of activity in the prefrontal cortex.

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