A growing number of applications of transcranial magnetic stimulation (TMS) as a research tool and clinical device have increased the need to understand optimal stimulation parameters. Repetitive TMS induces changes in cortical excitability, which are thought to underlie the neurobiological and behavioral changes following a course of treatment. The Hanlon Lab is determining how different stimulation parameters effect this cortical excitability. Using motor evoked potentials recorded by EMG electrodes, the long term effects of novel rTMS protocols (e.g., Theta-burst stimulation) on cortical excitability are being explored. These studies aim to optimize stimulation patterns, frequencies, and duration. In addition to rTMS, single pulse TMS is being investigated with interleaved TMS/BOLD fMRI. Using this method, the neurobiological effects of single pulseTMS at various cortical locations and at different intensities is being explored.
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