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843-876-2457

jianw@musc.edu

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Clinical Trials

Rank

Associate Professor

College

College of Medicine

Department

Microbiology and Immunology

Academic Focus

B cell dysfunction in HIV immuno-pathogenesis
Toll-like receptors and agonists, microbial translocation, gut permeability, antigen-presenting cells
Gender differences in immune function and disease pathogenesis, e.g., HIV, SLE

Faculty email addresses should not be used to seek medical advice or to make medical appointments. Please visit MyChart for medical appointments or to contact your provider.

Biography

Key differences in B cell activation patterns and immune correlates among treated HIV-infected patients versus healthy controls following influenza vaccination.

Luo Z, Ma L, Zhang L, Martin L, Wan Z, Warth S, Kilby A, Gao Y, Bhargava P, Li Z, Wu H, Meissner EG, Li Z, Kilby JM, Liao G, Jiang W.

Vaccine. 2016; 34(16):1945-55. NIHMSID: NIHMS747556

PubMed [journal]

PMID:: 26721328
PMCID:: PMC4803607

Select item at position 22.

Humoral immune responses to Streptococcus pneumoniae in the setting of HIV-1 infection.

Zhang L, Li Z, Wan Z, Kilby A, Kilby JM, Jiang W.

Vaccine. 2015; 33(36):4430-6. NIHMSID: NIHMS702031

PubMed [journal]

PMID:: 26141012
PMCID:: PMC4547882

Select item at position 33.

Soluble CD14 is a nonspecific marker of monocyte activation.

Shive CL, Jiang W, Anthony DD, Lederman MM.

AIDS (London, England). 2015; 29(10):1263-5. NIHMSID: NIHMS687458

PubMed [journal]

PMID:: 26035325
PMCID:: PMC4452959

Select item at position 44.

HIV-associated memory B cell perturbations.

Hu Z, Luo Z, Wan Z, Wu H, Li W, Zhang T, Jiang W.

Vaccine. 2015; 33(22):2524-9. NIHMSID: NIHMS678011

PubMed [journal]

PMID:: 25887082
PMCID:: PMC4420662

Select item at position 55.

Plasmacytoid dendritic cells mediate synergistic effects of HIV and lipopolysaccharide on CD27+ IgD- memory B cell apoptosis.

Zhang L, Luo Z, Sieg SF, Funderburg NT, Yu X, Fu P, Wu H, Jiao Y, Gao Y, Greenspan NS, Harding CV, Kilby JM, Li Z, Lederman MM, Jiang W.

Journal of virology. 2014; 88(19):11430-41.

PubMed [journal]

PMID:: 25056888
PMCID:: PMC4178795

Select item at position 66.

Cycling memory CD4+ T cells in HIV disease have a diverse T cell receptor repertoire and a phenotype consistent with bystander activation.

Jiang W, Younes SA, Funderburg NT, Mudd JC, Espinosa E, Davenport MP, Babineau DC, Sieg SF, Lederman MM.

Journal of virology. 2014; 88(10):5369-80.

PubMed [journal]

PMID:: 24522925
PMCID:: PMC4019138

Select item at position 77.

Sex Differences in monocytes and TLR4 associated immune responses; implications for systemic lupus erythematosus (SLE).

Jiang W, Gilkeson G.

Journal of immunotherapy applications. 2014; 1:1. NIHMSID: NIHMS570291

PubMed [journal]

PMID:: 25309746
PMCID:: PMC4193900

Select item at position 88.

Sex differences in monocyte activation in systemic lupus erythematosus (SLE).

Jiang W, Zhang L, Lang R, Li Z, Gilkeson G.

PloS one. 2014; 9(12):e114589.

PubMed [journal]

PMID:: 25485543
PMCID:: PMC4259347

Select item at position 99.

Microbial TLR Agonists and Humoral Immunopathogenesis in HIV Disease.

Yu X, Li Z, Zhou Z, Kilby JM, Jiang W.

Epidemiology (Sunnyvale, Calif.). 2013; 3:120. NIHMSID: NIHMS572915

PubMed [journal]

PMID:: 24795844
PMCID:: PMC4005894

Select item at position 1010.

Interferon-α is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers.

Hardy GA, Sieg S, Rodriguez B, Anthony D, Asaad R, Jiang W, Mudd J, Schacker T, Funderburg NT, Pilch-Cooper HA, Debernardo R, Rabin RL, Lederman MM, Harding CV.

PloS one. 2013; 8(2):e56527.

PubMed [journal]

PMID:: 23437155
PMCID:: PMC3577907

Bacterial colonization and beta defensins in the female genital tract in HIV infection.

Jiang W, Ghosh SK, Flyckt R, Kalinowska M, Starks D, Jurevic R, Weinberg A, Lederman MM, Rodriguez B.

Current HIV research. 2012; 10(6):504-12. NIHMSID: NIHMS400345

PubMed [journal]

PMID:: 22716110
PMCID:: PMC3427638

Select item at position 212.

Microbial Translocation and B Cell Dysfunction in Human Immunodeficiency Virus Disease.

Jiang W.

American journal of immunology. 2012; 8(2):44-51. NIHMSID: NIHMS480749

PubMed [journal]

PMID:: 23869197
PMCID:: PMC3712352

Select item at position 313.

Presentation of soluble antigens to CD8+ T cells by CpG oligodeoxynucleotide-primed human naive B cells.

Jiang W, Lederman MM, Harding CV, Sieg SF.

Journal of immunology (Baltimore, Md. : 1950). 2011; 186(4):2080-6. NIHMSID: NIHMS265059

PubMed [journal]

PMID:: 21239717
PMCID:: PMC3039025

Select item at position 414.

Intracellular Casp8p41 content is inversely associated with CD4 T cell count.

Cummins NW, Jiang W, McGinty J, Bren GD, Bosch RJ, Landay A, Deeks SG, Martin JN, Douek D, Lederman MM, Brenchley J, Badley AD.

The Journal of infectious diseases. 2010; 202(3):386-91. NIHMSID: NIHMS215916

PubMed [journal]

PMID:: 20565257
PMCID:: PMC2906377

Select item at position 515.

Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation.

Funderburg NT, Mayne E, Sieg SF, Asaad R, Jiang W, Kalinowska M, Luciano AA, Stevens W, Rodriguez B, Brenchley JM, Douek DC, Lederman MM.

Blood. 2010; 115(2):161-7.

PubMed [journal]

PMID:: 19828697
PMCID:: PMC2808148

Select item at position 616.

Desensitization to type I interferon in HIV-1 infection correlates with markers of immune activation and disease progression.

Hardy GA, Sieg SF, Rodriguez B, Jiang W, Asaad R, Lederman MM, Harding CV.

Blood. 2009; 113(22):5497-505.

PubMed [journal]

PMID:: 19299650
PMCID:: PMC2689050

Select item at position 717.

Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection.

Jiang W, Lederman MM, Hunt P, Sieg SF, Haley K, Rodriguez B, Landay A, Martin J, Sinclair E, Asher AI, Deeks SG, Douek DC, Brenchley JM.

The Journal of infectious diseases. 2009; 199(8):1177-85. NIHMSID: NIHMS106700

PubMed [journal]

PMID:: 19265479
PMCID:: PMC2728622

Select item at position 818.

Impaired naive and memory B-cell responsiveness to TLR9 stimulation in human immunodeficiency virus infection.

Jiang W, Lederman MM, Mohner RJ, Rodriguez B, Nedrich TM, Harding CV, Sieg SF.

Journal of virology. 2008; 82(16):7837-45.

PubMed [journal]

PMID:: 18524824
PMCID:: PMC2519583

Select item at position 919.

Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis.

Funderburg N, Luciano AA, Jiang W, Rodriguez B, Sieg SF, Lederman MM.

PloS one. 2008; 3(4):e1915.

PubMed [journal]

PMID:: 18382686
PMCID:: PMC2271052

Select item at position 1020.

TLR9 stimulation drives naïve B cells to proliferate and to attain enhanced antigen presenting function.

Jiang W, Lederman MM, Harding CV, Rodriguez B, Mohner RJ, Sieg SF.

European journal of immunology. 2007; 37(8):2205-13.

PubMed [journal]

PMID:: 17621369

Interferon-alpha differentially rescues CD4 and CD8 T cells from apoptosis in HIV infection.

Rodriguez B, Lederman MM, Jiang W, Bazdar DA, Gàrate K, Harding CV, Sieg SF.

AIDS (London, England). 2006; 20(10):1379-89.

PubMed [journal]

PMID:: 16791012

Select item at position 222.

Peripheral S-phase T cells in HIV disease have a central memory phenotype and rarely have evidence of recent T cell receptor engagement.

Sieg SF, Rodriguez B, Asaad R, Jiang W, Bazdar DA, Lederman MM.

The Journal of infectious diseases. 2005; 192(1):62-70.

PubMed [journal]

PMID:: 15942895

Select item at position 323.

Impaired monocyte maturation in response to CpG oligodeoxynucleotide is related to viral RNA levels in human immunodeficiency virus disease and is at least partially mediated by deficiencies in alpha/beta interferon responsiveness and production.

Jiang W, Lederman MM, Salkowitz JR, Rodriguez B, Harding CV, Sieg SF.

Journal of virology. 2005; 79(7):4109-19.

PubMed [journal]

PMID:: 15767412
PMCID:: PMC1061539

Wei Jiang MD

Rank

College

Department

Academic Focus

Locations

Office Location

street
room

Biography

Wei Jiang MD

Rank

College

Department

Academic Focus

Locations

Office Location street room

Biography

Office Location

street
room