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Katherine E. Twombley MD

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  • Professor
  • College of Medicine
  • Pediatrics
Academic Focus
  • Pediatric Kidney Transplantation
  • Pediatric Metabolic Bone Disease
  • Nephrotic Syndrome
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Katherine Twombley is a Professor with Tenure in the Department of Pediatrics at the Medical University of South Carolina (MUSC) in Charleston, SC. She is the Chief of Pediatric Nephrology and the Medical Director of the Pediatric Kidney Transplant Program. She is also the Medical Director of the Acute Dialysis Units in the MUSC Charleston Healthcare System. She is very active in the American Society of Transplantation and she is the Chair of the Pediatric Community of Practice.

Education & Training:
College of Charleston, 1996, B.A. in Biology
Medical University of South Carolina, 2004, M.D. in Medicine
Miami Children’s Hospital, 2007, Residency in Pediatrics
University of Southwestern Medical Center, 2010, Fellowship in Pediatric Nephrology

Research Interests:

A central focus of Dr. Twombley’s research is in antibody mediated rejection (AMR) and its long term effects such as hypertension, donor specific antibody development and chronic kidney disease. I am currently the PI on a multicenter grant with the Midwest Pediatric Nephrology Consortium where we are investigating the complications of kidney transplantation. My long-term goals consist of a clinical focus on pediatric kidney transplantation, while academically I aspire to continue to be a productive and responsible independent clinical/translational investigator and educator. I have worked on multi-institutional projects as well as institutional projects.

Highlight Publications:

Gattineni J, Bates C, Twombley K, Dwarakanath V, Robinson ML, Goetz R, Mohammadi M, Baum M. (2009) FGF23 decreased renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.  Am J Physiol Renal Physiol. 297(2): F282-91.
Twombley K, Gattineni J, Bobulescu IA, Dwarakanath V, Baum M. (2010) Effect of Metabolic Acidosis on Neonatal Proximal Tubule Acidification. Am J Physiol Regul Integr Comp Physiol
Habib S, Gattineni J, Twombley K, Baum M. (2010) Evidence That Prenatal Programming of Hypertension by Dietary Protein Deprivation Is Mediated by Fetal Glucocorticoid Exposure. Am J Hypertens
Gattineni J, Twombley K, Goetz R, Mohammadi M, Baum M. (2011) Regulation of Serum 1,25(OH)2 Vitamin D3 levels by Fibroblast Growth Factor 23 is mediated by FGF Receptors 3 and 4. Am J  Physiol Renal Physiol.,
Joseph C, Twombley K, Gattineni J, Zhang Q, Dwarakanath V, Baum M (2011) Acid Increases NHE8 Surface and Activity in NRK Cells, Am J Physiol Renal Physiol.
Baum M, Twombley K, Gattineni J, Joseph C, Wang L, Zhang Q, Dwarakanath V, Moe OW. (2012) Proximal tubule Na+/H+ exchanger activity in adult NHE8-/-, NHE3-/-, and NHE3-/- /NHE8-/- mice. Am J Physiol Renal Physiol., 303(11): F1495-502.
Twombley K, Thach L, Ribeiro A, Joseph C,Seikaly MG (2013) Acute Antibody Mediated Rejection in Pediatric Kidney Transplants: A Single Center Experience. Pediatric Transplant, doi: 10.1111/petr.12129.
Connelly J1, Pilch N, Oliver M, Jordan C, Fleming J, Meadows H, Baliga P, Nadig S, Twombley K, Shatat I, Taber D. (2015) Prediction of medication non-adherence and associated outcomes in pediatric kidney transplant recipients. Pediatr Transplant, PMID: 25917112
Kizilbash S, Claes D, Ashoor I, Chen A, Jandeska S, Matar RB, Misurac J, Sherbotie J, Twombley K, Verghese P. (2017) Bortezomib in the treatment of antibody mediated rejection in pediatric kidney transplant recipients: A multicenter Midwest Pediatric Nephrology Consortium study. Pediatr Transplant., PMID: 28092129
Nazario M, Nicoara O, Becton L, Self S, Hill J, Mack E, Evans M, Twombley K. (2018) Safety and utility of surveillance biopsies in pediatric kidney transplant patients. Pediatric Transplant. PMID: 29582530.
Jordan CL, Taber DJ, Kyle MO, Connelly J, Pilch NW, Fleming J, Meadows HB, Bratton CF, Nadig SN, McGillicuddy JW, Chavin KD, Baliga PK, Shatat IF, Twombley K. (2015) Incidence, risk factors, and outcomes of opportunistic infections in pediatric renal transplant recipients. Pediatric Transplant., PMID: 26576516.
Twombley K, Pokala H, Ardura MI, Harker-Murray P, Johnson-Welch SF, Weinberg A, Seikaly M. (2012) Intraventricular rituximab and systemic chemotherapy for treatment of central nervous system post-transplant lymphoproliferative disorder after kidney transplantation. Pediatr Transplant.
Murphy HJ, Eklund ML, Hill J, Morella K, Cahill JB, Kiger JR, Twombley KE, Annibale DJ. (2019) Early continuous renal replacement therapy during infant extracorporeal life support is associated with decreased lung opacification. J Artif Organs., 34(8):1435-1445. PMID: 31342287
Vincent K, Murphy HJ, Ross JR, Twombley KE. (2019) Acute Kidney Injury Guidelines are Associated with Improved Recognition and Follow-up for Neonatal Patients. Adv Neonatal Care, PMID: 31567184