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Peggi Angel Ph.D.

Peggi Melissa Angel Ph.D.

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Rank
  • Assistant Professor
College
  • College of Medicine
Department
  • Cell and Molecular Pharmacology and Experimental Therapeutics
Academic Focus
  • Deciphering the “collagen switch” in racial disparities of breast cancer. My laboratory has developed novel proteomic workflows that integrate 2D maps of collagen proteins with microscopy studies of breast cancer (Figure 2, based on 2018, Angel et al, Clinical Proteomics Appl). Using these techniques, we are defining critical ancestry-dependent changes in post-translational regulation of collagen types from triple negative breast tumors.
  • Development of high throughput N-glycan assays by imaging mass spectrometry. My laboratory has recently developed a high throughput approach to scan cell N-glycoforms from as few as 3,000 cells. This project further advances approaches to define N-glycan structure through simplified workflows on cells types from cancer and cardiovascular diseases.
  • Extracellular matrix remodeling in liver, lung and cardiovascular disease. This project further advances imaging mass spectrometry of extracellular matrix proteomics by defining cell type niches that produce aberrant collagen. This project focuses specifically on determining new ways to quantitatively measure post-translational regulation and site mutations of collagen type I (COL1A1 and COL1A2) and collagen type III (COL3A1) in liver fibrosis, lung adenocarcinoma, and cardiovascular remodeling
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Biography

1999, BS Chemistry, ACS certified

2007, Ph.D, University of Georgia, "Quantative Proteomics in Developmental Biology"

2007-2008 Postdoctoral Fellowship, Emory University "Fetal Alcohol Syndrome & Alcohol-induced Mitochondrial Post-translational Modifications in Liver Disease"

2008-2011 Postdoctoral Fellowship, Vanderbilt University Medical Center "Systems-based Consortium for Organ Design and Engineering: Heart Valves"