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Raymond N. DuBois MD, PhD

Director, Hollings Cancer Center

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  • Professor
  • College of Medicine
  • Biochemistry and Molecular Biology
Academic Focus
  • Cancer prevention, tumor microenvironment, inflammation and cancer
  • colorectal cancer biology, early disease progression
  • Intestinal epithelial biology, cancer stem cell biology, cancer interception
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Raymond N. DuBois, M.D., Ph.D., was named Dean of the College of Medicine at the Medical University of South Carolina in March of 2016 and in 2020 he was named as Director of MUSC Hollings Cancer Center.  Prior to these positions, Dr. DuBois served as Executive Director of the Biodesign Institute in Arizona (ASU) and held the Dalton Chair of Chemistry and Biochemistry with a joint appointment as Professor of Medicine in the Mayo College of Medicine.  From 2007 to 2012, he served as Provost and Executive Vice President at the University of Texas MD Anderson Cancer Center in Houston and held the Ellen Knisely Distinguished Chair in Colon Cancer Research.  During his tenure at Vanderbilt University Medical Center (1991-2007) he served as Director of the Division of Gastroenterology, Hepatology & Nutrition as well as Director of the Vanderbilt-Ingram Cancer Center. In 2015 he was honored at Vanderbilt by inclusion as an honorary member in the Tinsley Harrison Society at the Vanderbilt University School of Medicine.
Dr. DuBois is an internationally renowned expert and is known for his work elucidating the role of inflammation and inflammatory mediators in the progression of colon cancer.  His laboratory examines the molecular mechanisms by which inflammatory mediators affect epithelial biology, the tumor microenvironment and cancerization.  In the 1990s, DuBois and colleagues made the landmark discovery that colorectal tumors contained high levels of a key enzyme (COX-2) which regulates prostaglandin production.  COX-2 catalyzes a key step in the production of pro-inflammatory mediators leading to the production of prostaglandin E2 (PGE2).  This work and other studies unveiled a better understanding of the role of anti-inflammatory agents, like aspirin, in reducing cancer risk which led to clinical trials, showing how drugs that inhibit this pathway could prevent or intercept the process of cancer development early on.  More recent studies have revealed that PGE2 regulates the immune status of the tumor microenvironment and inhibitors of PGE2 signaling block tumor metastasis and cancer progression.
Dr. DuBois was elected as a member of the National Academy of Medicine in October of 2019 and currently is a Fellow of the American Association for the Advancement of Science (AAAS), the Royal College of Physicians (London) and the Academy of the American Association for Cancer Research (AACR); and in 2019, he was awarded the AACR Margaret Foti Award for Leadership and Extraordinary Achievements in Cancer Research. Other major awards for his cancer research include the Richard and Hinda Rosenthal Research Award, the Dorothy P. Landon-AACR Cancer Prize and the Anthony Dipple Carcinogenesis Award given by Oxford University Press. He is a past president of AACR, the Southern Society for Clinical Investigation, and the International Society for Gastrointestinal Cancer.  He currently serves as President and Chair of the AACR Foundation Board.  In 2018, he was named to the steering committee for the AACR Academy, and selected as a Vice Chair for the Stand Up to Cancer (SU2C) Scientific Advisory Board. He is also a member of the American Clinical and Climatological Association, the Association of American Physicians and the American Society for Clinical Investigation. Dr. DuBois also serves as an editor-in-chief for Cancer Prevention Research, published by AACR.
During his career as a physician-scientist, DuBois has published over 160 peer reviewed research articles, more than 60 review articles, 25 book chapters, and three books. His work has been cited over 60,000 times according to Google Scholar (H-index=114).  He is also a co-inventor of a method to identify and target cellular genes needed for viral growth as well as cellular genes that function as tumor suppressors in mammals.
DuBois earned a bachelor’s degree (Biochemistry w/honors) from Texas A&M University and a doctoral degree (Biochemistry) from The University of Texas Southwestern Medical Center in Dallas.  He obtained a medical degree from The University of Texas School of Medicine in San Antonio, followed by completion of an Osler Medicine internship/residency, and a gastroenterology fellowship at the Johns Hopkins Hospital in Baltimore. In 2007 he was honored at Hopkins by being inducted into the Johns Hopkins University Society of Scholars.