Education and Training
2012-2018 Postdoctoral Fellow, Beth Israel Deaconess Medical Center, Harvard Medical School
2007-2012 Ph.D., Peking University, Beijing, P.R. China.
2001-2005 B.S., Biotechnology, Guangxi University, Nanning, P.R. China.
Research
A major research focus in my new laboratory is to investigate the roles of arginine methylation in cell signaling, epigenetics, metabolism, and cancers. Protein arginine methylation is one of the most common posttranslational modifications and plays critical roles in various fundamental cellular processes. Aberrant expression of protein arginine methyltransferases (PRMTs) is frequently observed in various cancers. Their high expression is associated with poor survival of cancer patients. We are interested in understanding how arginine methylation is regulated, how arginine methylation contributes to cancers, and how to target arginine methylation pathway in cancers. Our goals are to advance current knowledge of arginine methylation biology and to identify novel targets/strategies to target the arginine methylation pathway for cancer therapy. We employ a range of methods in our studies, including biochemistry, molecular and cellular biology, transcriptomic/proteomic/metabolomic approaches, cancer cell lines, xenograft mouse models, genetic mouse models, and cancer patient samples.