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Mushfiquddin Khan PhD

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  • Professor
  • College of Medicine
  • Pediatrics
Academic Focus
  • Neuropharmacology (Stroke, spinal cord injury and traumatic brain injury). Role of AMP kinase and HIFs in functional recovery following acute and chronic brain injury.
  • Lipid signaling in neurodegenerating and demyelinating diseases.
  • Role of oxidative stress and reactive lipids in neurodegenerative diseases
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Education & Training:
Aligarh Muslim University, India, 1976, B.Sc. in Chemistry
Aligarh Muslim University, India, 1978, M.Sc. in Organic Chemistry
Aligarh Muslim University, India, 1983, Ph.D. in Bioorganic Chemistry
Medical University of South Carolina, 1994, in Neuropharmacology

Research Interests:
My research interest is to investigate the neuropharmacology of CNS trauma with a major focus on stroke (cerebral ischemia and reperfusion; IR, and permanent ischemia), traumatic brain injury (TBI) and spinal cord injury (SCI). The investigations have targeted both neuroprotection and neurorestoration for optimal functional recovery of neurobehavioral and cognitive functions following stroke. My bioorganic background and neuropharmacology training prepared me to study design, prepare and administer drugs to animals and monitor their efficacy. These studies helped me to develop expertise in animal models (rat and mouse) of acute/chronic brain injury (IR and TBI), evaluation of neurobehavioral and neurological functions, measurements of physiologic parameters as well as cerebral blood flow and physiological parameters. To understand the neurorestoration mechanisms, I devoted my efforts to investigating the role of proteases and lipases in neuronal cell death. I remained focused on neurovascular protection and cross talk between endothelial cells, neurons and glial cells.

Highlight Publications:

Khan M, Sekhon B, Giri S, Jatana M, Gilg AG, Ayasola K, Elango C, Singh Ak & Singh l (2005), S-nitrosoglutathione inhibits inducible nitric oxside synthases expression and protects brain form focal cerebral ischemia in a rat model of experimental stroke. J. Cerev. Blood Flow & Metab., 25:177-192, PMID: 15647746

Khan M, Jatana M, Elango C, Paintlia AS, Sign AK and Singh l (2006) Cerebrovascular protection by various nitric oxide donors in rats after experimental stroke, Nitric Oxide, 15:114-124, PMID: 1652450

Khan M, Singh J, Singh l (2008), Plasmalogen deficiency in cerebral adrenoleukodystrophy and its modulation by lovastatin. J. Neurochem., 106: 1766-1779, PMID: 18540993

Khan M, Singh J, Gilg AG, Uto T, Singh l (2010), Very long-chain fatty acid accumulation causes lipotoxic response via 5-lipoxygenase in cerebral adrenoleukodystrophy. J. Lipid Res., 51: 1685-1695, PMID: 20195242

Singh J., Khan M, Singh l (2011), HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and down regulates the expression of proinflammatory cytokines in Abcd 1/2-silenced mouse astrocytes. J Lipid Res., 52: 2056-2069, PMID: 21891797 

Khan M, Sakakima H, Dhammu TS, Shunmugavel A, lm Y, Gilg AG, Singh AK and Singh l (2011), S-nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats. J. Neuroinflammation, 8:78, PMID: 21733162

Sakakima H, Khan M, Dhammu TS, Shunmugavel A, Yoshida Y, Singh l and Singh AK (2012), Stimulation of functional recovery via the mechanisms of neurorepair by S-nitrosoglutathione and motor exercise in a rat model of transient cerebral ischemia and reperfusion. Restorative Neurology and Neurosci., 30: 527-528, PMID: 22717646

Khan M, Dhammu TS, Matsuda F, Baarine M, Dhindsa TS, Singh l, Singh AK (2015), Promoting endothelial function by S-nitrosoglutathione through the HIF-1a/VEGF pathway stimulates neurorepair and functional recovery following experimental stroke in rats. Drug Design, Development and Therapy, 9:2233-2247, PMID: 25945035

Khan M, Dhammu TS, Matsuda F, Singh I (2015), Blocking a vicious cycle nNOS/peroxynitrite/AMPK by S-nitrosoglutathione: implication for stroke therapy. BMC Neurosci., 16: 42, PMID: 26174015

Baarine M, Khan M, Singh A, Singh l (2015), Functional characterization of iPSC-derived brain cells as model for X-adrenoleukodystrophy. Plos One 10: e0143238, PMID: 265581106

Khan M, Dhammu T, Matsuda F, Annamalai B, Dhindsa T, Singh l, Singh AK (2016), Targeting the nNOS/peroxynitrite/calpain system to confer neuroprotection and aid functional recovery in a mouse model of TBl, Brain Res., 1630: 159-170, PMID: 26596859

Khan M, Dhammu T, Baarine M, Kim J, Paintlia MK, Singh l, Singh AK, (2018), GSNO promotes functional recovery in experimental TBl by stabilizing HlF-1Uα. Behav Brain Res., 340:63-70, PMID: 27780722

Khan M, Shunmugavel A, Dhammu TS, Khan H, Singh I, Singh AK (2018), Combined treatment with GSNO and CAPE accelerates functional recovery via additive antioxidant activities in a male mouse model of TBI. J. Neurosci. Res. 96(12), 1900-1913, PMID: 30027580

Khan M, Dhammu T, Singh l, Singh AK (2018), Amelioration of spinal cord injury in rats by blocking peroxynitrite/calpain activity. BMC Neurosci., 19:50, PMID: 30103682

Khan M, Dhammu T, Qiao F, Kumar P, Singh AK, Singh I (2019), S-nitrosoglutathione mimics the beneficial activity of endothelial nitric oxide synthase-derived nitric oxide in a mouse model of stroke. J Stroke and Cerebrovasc Dis. 28(12), 104470, PMID: 31680031