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Hesheng Liu PhD

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  • Professor
  • College of Medicine
  • Neuroscience
Academic Focus
  • Systems Neuroscience; Surgical Planning; Schizophrenia; OCD; Epilepsy; Stroke
  • Functional MRI; TMS; DBS; EEG; MEG
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Dr. Liu received his B.S., M.S., and Ph.D degrees from Tsinghua University, China. He is Endowed Chair Professor of Neuroscience at MUSC and Associate Professor of Radiology at Harvard Medical School. His research focuses on developing novel neuroimaging and computational tools to reveal brain functional architecture in individual subjects. A major goal of his work is to localize functional networks in individual subjects to guide surgical intervention. Another theme in his lab is to identify personalized neuromodulation targets for brain disorders and study functional changes in individual patients after neuromodulation treatments.



   Selected Publications:


1.    Stoecklein S., Hilgendorff A., Li M., Förster K., Flemmer A.W., Galiè F., Wunderlich S., Wang D., Stein S., Ehrhardt H., Dietrich O., Zou Q., Zhou S., Ertl-Wagner B., Liu H. “Variable Functional Connectivity Architecture of the Preterm Human Brain: Impact of Developmental Cortical Expansion and Maturation”, Proc. Natl. Acad. Sci. USA. 2019 (in press)


2.     Li M., Wang D., Ren J., Langs G., Stoecklein S., Brennan B.P., Lu J., Chen H., Liu H., “Performing group-level functional image analyses based on homologous functional regions mapped in individuals”, PLoS Biology, 17 (3), e2007032, 2019


3.     Wang D., Li M., Wang M., Schoppe F., Ren J., Chen H., Ongur D., Baker J.T., Liu H., “Individual-specific functional connectivity markers track dimensional and categorical features of psychotic illness”, Mol. Psychiatry, 2018


4.     Tang W.#Liu H.#, Douw L., Kramer M.A., Eden U.T., Hämäläinen M.S., Stufflebeam S.M.,  “Dynamic connectivity modulates local activity in the core regions of the default-mode”, Proc. Natl. Acad. Sci. USA., 114(36): 9713–9718, 2017 (# co-corresponding authors).


5.     Wang D., Buckner R.L., Fox M.D., Holt D.J., Holmes A.J., Mueller S., Langs G., Pan R., Qian T., Li K., Baker J., Stufflebeam S.M., Wang K., Wang X., Hong B., Liu H. “Parcellating Cortical Functional Networks in Individuals”, Nat. Neurosci. 18:1853–1860, 2015.


6.     Mueller S., Wang D., Pan R., Holt D., Liu H., “Abnormalities in hemispheric specialization of caudate nucleus connectivity in schizophrenia”. JAMA Psychiatry. 72(6):552-560, 2015.


7.     Zeng L., Wang D., Fox M.D., Sabuncu M., Hu D., Ge M., Buckner R.L., Liu H., “Neurobiological basis of head motion in brain imaging”. Proc. Natl. Acad. Sci. USA. 111(16):6058-62, 2014.


8.     Wang D., Buckner R.L., Liu H., “Functional Specialization in the Human Brain Estimated By Intrinsic Hemispheric Interaction”. J Neurosci. 34 (37):12341-12352, 2014.


9.     Mueller S., Wang D., Fox M.D., Yeo B.T.T., Sepulcre J., Sabuncu M.R., Shafee R., Lu J., Liu H.,“Individual variability in functional connectivity architecture of the human brain”, Neuron, 77(3): 586-595, 2013.  


10.      Lu, J.*, Liu, H.*, Zhang, M., Wang, D., Cao, Y., Ma, Q., Rong, D., Wang, X., Buckner, R.L., and Li, K.“Focal pontine lesions provide evidence that intrinsic functional connectivity reflects polysynaptic anatomical pathways”. J. Neurosci. 31:15065–15071, 2011. (* co-first authors).


11.  Liu H., Stufflebeam S.M., Sepulcre J., Hedden T., Buckner R.L., “Evidence from Intrinsic Activity that Asymmetry of the Human Brain is Controlled by Multiple Factors”, Proc. Natl. Acad. Sci. USA, 106: 20499-20503, 2009.


12.  Liu. H., Agam Y., Madsen J.R., Kreiman G., “Timing, timing, timing: fast decoding of object information from intracranial field potentials in human visual cortex”, Neuron, 62: 281-290, 2009.