Education & Training:
Wittenberg University, Springfield, 1977, B.A. in Biology & East Asian Studies
Case Western Reserve University, 1983, D.D.S in Dentistry
University of Michigan, 1991, M.P.H in Dental Public Health
University of Michigan, 1992, Certificate in Residency, Dental Public Health
University of Michigan, 1996, Dr.P.H. in Epidemiology, Oral Diseases
Research Interests:
My background includes dentistry, epidemiology and public health; and each with an emphasis in research and research methodology. My current research focuses on why some children’s tooth enamel develops with structural integrity and other children have defective tooth enamel. In general, tooth enamel does not remodel and therefore serves as a record of exposures during its development. My goal is to identify potentially modifiable exposures that occur during pregnancy, through birth and early infancy that result in defective enamel. The enamel for a child’s front teeth develops from about 12 weeks’ gestation though a few weeks after birth, so then is the time period for exposures. When the teeth erupt into the oral cavity at about 1 year of age or older, we take digital photos of the teeth and then reference the defects back to the time of the exposures. I joined the Department of Pediatrics and Darby Children’s Research Institute to focus on the oral health outcomes for the mothers and children who participate in the clinical trials of maternal vitamin D supplementation during pregnancy. This collaboration fits superbly as the major components of vitamin D metabolism and calcium homeostasis are many of the same as those involved in tooth enamel development. I am certified by the American Board of Dental Public Health and committed to the conduct of clinical studies that can provide evidence for future action to improve the public’s dental health.
Highlight Publications:
1. Reed SG, Miller CS, Wagner CL, Hollis BW, Lawson AB (2020), Toward preventing enamel hypoplasia: Modeling maternal and neonatal biomarkers of human calcium homeostasis. Caries Res., 54:55-67. PMID: 31665727 ,PMCID:PMC7299520
2. Wagner CL, Hulsey TC, Ebeling M, Shary JR, Asghari G, Howard CR, Baatz JE, Newton DA, Wahlquist AE, Reed SG, Taylor SN, Lawrence RA, Hollis BW (2020). Safety aspects of a randomized clinical trial of maternal and infant vitamin D
3. Hajizadeh S, Shary JR, Reed SG, Wagner CL. (2019), The prevalence of hypovitaminosis D and its risk factors in pregnant women and their newborns in the Middle East: A systematic review. Int. J. of Reproductive BioMed., 17: 685-708, PMID: 31807718, PMCID:PMC6844283
4. Reed SG, Voronca D, Wingate JS, Murali M, Lawson AB, Hulsey TC, Ebeling MD, Hollis BW, Wagner CL. (2017), Prenatal vitamin D and enamel hypoplasia in human primary maxillary central incisors: a pilot study, Pediatric Dental J., 27: 21-28, PMID: 30100673, PMCID: PMC6086375
5. Reed SG, Manz MC, Snipe SM, Ohshima M, Wagner CL. (2015), Feasibility study of a salivary occult blood test to correlate with periodontal measures as indicators of periodontal inflammation in a population of pregnant women. J Oral Science., 57:55-58, PMID: 25807909 PMCID: PMC4519090
6. Reed SG, Cunningham JE, Latham TN, Shirer SC, Wagner CL (2014), Maternal oral mutans streptococci (MS) status, not breastfeeding, predicts predentate infant oral MS status. Breastfeeding Med., 9: 446-449. PMID: 25290343, PMCID: PMC4216516