Onder Albayram PhD
(843) 876-2217
albayram@musc.edu
68 President Street, Bioengineering Building, Charleston, SC 29403 Room Office: BEB414 Laboratory: BEB431
Faculty email addresses should not be used to seek medical advice or to make medical appointments. Please visit MyChart for medical appointments or to contact your provider.
Department
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Pathology and Laboratory Medicine
Academic Focus
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Mechanistic and Causative Role of p17 in Mediating Endogenous Neuroprotective Mitochondrial Stress Response in Neurodegeneration and Brain Injury
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Mechanisms Underlying the Distinct Age-Dependent Effects of the Endocannabinoid Systems Activity in the Brain
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Mechanistic Role of Meningeal Lymphatic Vasculature and Immunity in the Brain, Aging and Neurodegenerative Diseases
Faculty email addresses should not be used to seek medical advice or to make medical appointments. Please visit MyChart for medical appointments or to contact your provider.
Biography
Dr. Albayram is an Assistant Professor in the Department of Medicine, Department of Pathology and Laboratory and Department of Neuroscience at the Medical University of South Carolina. Dr. Albayram has completed a M.S. in neuropharmacology at the Department of Pharmacological Sciences, University of Southern California in Los Angeles, California. He has completed the Ph.D. in Neurobiology at the Institute of Molecular Psychiatry, University of Bonn in Germany. Dr. Albayram completed his faculty training in Translational Neuroscience perspective at Harvard Medical School.
His research focuses on three principal areas: 1) The functions and relationships of the glymphatic system and brain lymphatics in health and disease. 2) Cellular and molecular mechanisms mediating mitochondrial stress response in brain aging and its involvement in trauma- ans stress-mediated brain disorders; 3) Cellular and molecular mechanisms underlying the distinct age-dependent effects of the cannabinoid system activity in the brain.
Selected Publications
- Karakaya, E., Oleinik, N., Edwards, J., Tomberlin, J., Barker, R.B., Berber, B., Ericsson, M., Alsudani, H., Ergul, A., Beyaz, S., Lemasters, J.J., Ogretmen, B., Albayram, O. (2024) p17/C18-ceramide-mediated mitophagy is an endogenous neuroprotective response in preclinical and clinical brain injury PNAS Nexus
- Bilkei-Gorzo A*, Albayram O*, Draffehn A, Michel K, Piyanova A, Oppenheimer H, Dvir-Ginzberg M, Rácz I, Ulas T, Imbeault S, Bab I, Schultze JL, Zimmer A. (2017) A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice. Nature Medicine
- Albayram, M.S., Tufan, F., Smith, G., Tuna, I.S., Zile. M, and Albayram, O. (2022) Non-invasive MR imaging of the ventral and dorsal lymphatic networks with connections to cervical lymph nodes in the human brain Nature Communications
- Kondo A, Shahpasand K, Mannix R, Qiu J, Moncaster J, Chen CH, Yao Y, Lin YM, Driver JA, Sun Y, Wei S, Luo ML, Albayram O, Huang P, Rotenberg A, Ryo A, Goldstein LE, Pascual-Leone A, McKee AC, Meehan W, Zhou XZ, Lu KP.(2015) Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy. Nature
- Albayram O, Kondo A, Mannix R, Smith C, Tsai CY, Li C, Herbert MK, Qiu J, Monuteaux M, Driver J, Yan S, Gormley W, Puccio AM, Okonkwo DO, Lucke-Wold B, Bailes J, Meehan W, Zeidel M, Lu KP, Zhou XZ. (2017) Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae. Nature Communications
- Albayram O, Alferink J, Pitsch J, Piyanova A, Neitzert K, Poppensieker K, Mauer D, Michel K, Legler A, Becker A, Monory K, Lutz B, Zimmer A, Bilkei-Gorzo A. (2011) Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging. PNAS
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