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Alexander Awgulewitsch PhD

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(843) 792-8946

awgulewa@musc.edu

171 Ashley Ave Room CRI 606

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Rank
  • Professor
College
  • College of Medicine
Department
  • Medicine
Academic Focus
  • HOX gene-specified positional identities during embryonic development, as well as their maintenance and significance in adult tissues and disease processes. The latter is of relevance for topographically restricted diseases of the cardio-vascular system.
  • Analysis of HOX-regulated gene networks. Using hair follicle differentiation as a convenient and easily accessible model system facilitates the isolation of a significant number of HOX target genes of diverse functional categories. Many of these HOX-target gene regulatory mechanisms are of universal relevance.
  • Genetically engineered mouse technology. Use of this technology at MUSC has been pioneered (Awgulewitsch & Jacobs, 1992) and largely driven by my lab and my role as director of the Transgenic and Genome Editing (TGE) Core that routinely uses CRISPR-mediated genome editing methods.
Faculty email addresses should not be used to seek medical advice or to make medical appointments. Please visit MyChart for medical appointments or to contact your provider.

Locations

Office Location
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Biography

During my postdoctoral studies at Yale University, I became very much interested in studying the function of HOX transcriptional regulators in controlling embryonic patterning and their role in certain mammalian disease processes. This remained the focus during my academic appointments at MUSC, initially with the Department of Biochemistry and Molecular Biology in 1988, and later with the Department of Medicine and the Department of Regenerative Medicine and Cell Biology.