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Joseph Delaney PhD

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Rank
  • Assistant Professor
College
  • College of Medicine
Department
  • Biochemistry and Molecular Biology
Academic Focus
  • Copy-number alterations in cancer
  • Development of user-friendly bioinformatics
  • Translational studies of ovarian cancer
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Locations

Office Location
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Biography

Research

The Delaney Lab primarily investigates the biogenesis and phenotypic effects of copy-number alterations in cancer.

Oncogenesis is normally thought of as a process that involves mutations within specific genes to drive tumor development and progression. However, bioinformatic analysis shows that about half of all tumors in certain types of cancer can have insufficient mutations to yield cancer. For example, 48% of serous ovarian cancers have a mutation in p53, a quintessential tumor suppressor gene, but no other driver mutation. Yet, up to two-thirds of the average ovarian cancer genome has a copy number alteration. Since few labs seek to understand how these alterations originate and contribute to cancer biology, we help to fill that niche.