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Raymond N. DuBois M.D., Ph.D.

Dean, College of Medicine

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  • Professor
  • College of Medicine
  • Biochemistry and Molecular Biology
Academic Focus
  • Cancer prevention, tumor microenvironment, inflammation and cancer
  • colorectal cancer biology, early disease progression
  • Intestinal epithelial biology, cancer stem cell biology, cancer interception
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Raymond N. DuBois is currently Professor of Biochemistry, Molecular Biology and Dean of Medicine at the Medical University of South Carolina in Charleston.  After earning a PhD in biochemistry at the University of Texas Southwestern Medical Center in Dallas, Texas (1981), Dr. DuBois obtained his medical degree from the University of Texas Medical School in San Antonio (1985).  He then completed residency training in internal medicine and fellowship training in Gastroenterology at The Johns Hopkins Hospital in Baltimore, Maryland.  Dr. DuBois is an internationally renowned cancer researcher and leader in the cancer community.  He is known for elucidating a key role of prostaglandins (PGs) and other inflammatory mediators in colorectal cancer, which facilitated clinical trials targeting this pathway in humans for cancer prevention. His work also confirmed the existence of a novel tumor suppressor gene in the PG pathway (15-PGDH) in colon cancer which is responsible for inactivation of PGs. His research revealed that prostaglandins in the tumor microenvironment increase immune tolerance and resistance to therapy. He demonstrated that the downstream signaling pathways responsible for these effects reside in the PPARdelta nuclear receptor and cell surface PG receptors.  Dr. DuBois has also served in numerous institutional leadership roles (Division Chief, Cancer Center Director, Provost, EVP, Research Institute Director, Dean of Medicine), President of the American Association for Cancer Research (AACR) and the AACR Foundation and on key advisory boards for the NCI, NIDDK, AGA, Keystone Symposia, the Kleberg Foundation and the Stand Up to Cancer Foundation, which raises awareness for prevention and major research funding.  Working with AACR and the Stand Up to Cancer Foundation, Dr. DuBois helps fundraise and oversee research supported by the Foundation.