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Wei Jiang MD

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  • Professor
  • College of Medicine
  • Microbiology and Immunology
Academic Focus
  • Microbiome, B cell/autoantibody, and disease pathogenesis (HIV/SLE/Addictive Drug) Clinical/translational research
  • R01DA055523, multiPI Fitting & Jiang, 9/29/2022-7/30/2027, Investigating the effect of oral microbiome on cognition in HIV-infected chronic cannabis users. R03DA057164, Jiang (PI), 8/4/2022-8/3/2024, Investigate B cell perturbations and immune reconstitution failure in response to antiretroviral therapy in HIV-infected cocaine users. MUSC Team Translational Science Award,Jiang & Benitez (multiPI), 7/1/2022-6/30/2024, Investigate the impact of oral microbiome on cognition in Alzheimer’s
  • VA Medical Center CSRD Merit I01 CX002422, Jiang (PI), 3/1/2022-2/28/2026, Investigate the mechanism of autoreactive B cell-mediated immunological failure despite virologic suppression in HIV-infected individuals on antiretroviral therapy. NIH/NIAID R01AI128864, Jiang (PI), 05/01/17-4/30/2023 (NCE), On the pathogenic role of anti-CD4 antibody in poor CD4+ T cell recovery after antiretroviral therapy in HIV disease.
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1. Luo Z, Wu Yx, Meng Z, Martin L, Zhang L, Ogunrinde E, Zhou Z, Qin S, Wan Z, Westerink M, Warth S, Liu H, Jin P, Stroncek D, Li QZ, Wang E, Wu X, Heath S, LiZ, Alekseyenko A, JiangW*. Systemictranslocation of Staphylococcus drives autoantibody production in HIV disease. Microbiome. 2019. Feb 14;7(1):25. doi: 10.1186/s40168-019-0646-1. PMID: 30764863. *Awarded as the 2019 high impact research publication by the Dean, College of Medicine, Medical University of SouthCarolina.

2.Ogunrinde E, Zhou Z, Luo Z, Alekseyenko A, Li QZ, Macedo D, Kamen DL, Oates JC, Gilkeson GS, Jiang W*. A link between plasma microbial translocation, microbiome, and autoantibody development in first- degree relatives of systemic lupus erythematosus patients. Arthritis & Rheumatology. 2019. May 20. doi: 10.1002/art.40935.PMID:31106972

3. Luo Z, Fitting S, Robinson C, Benitez A, Li M, Wu Y, Fu X, Amato D, Ning W, Funderburg N, Wang X, Yu X, Wagner A, Cong X, Xu W, Maas K, McRae-Clark A, Hamlett E*, Jiang W*. Chronic cannabis smoking-enriched oral pathobiont drives behavioral changes and increases β-amyloid protein production in the brain. EbioMedicine. 2021 Nov 23;74:103701. doi:10.1016/j.ebiom.2021.103701. PMID: 34826801, PMCID: PMC8626580

4.  Luo Z, Health SL, Li M, Yang H, Wu Y, Collins M, Deeks SG, Martin JN, Scott A*, Jiang W*. Variation in blood microbial lipopolysaccharide (LPS) contributes to immune reconstitution in response to suppressive antiretroviral therapy in HIV. EbioMedicine. 2022 Apr 29;80:104037. doi: 10.1016/j.ebiom.2022.104037. PMID:35500539

5. Ning W, Cheng D, Howe PD, Bian C, Kamen DL, Luo Z, Fu X, Ogunrinde E, Yong L, Wang X, Li QZ, Qates J, Zhang W, White D, Wan Z, Gilkeson GS*, Jiang W*Staphylococcus aureus peptidoglycan (PGN) induces pathogenic autoantibody production via autoreactive B cell receptor clonal selection, implications in systemic lupus erythematosus. Journal of Autoimmunity. 2022. Jul 7;131:102860. doi: 10.1016/j.jaut.2022.102860. PMID: 35810689