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Wei Jiang MD

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  • Associate Professor
  • College of Medicine
  • Microbiology and Immunology
Academic Focus
  • Microbiome, B cell dysfunction, pathogenic autoantibody, drug of abuse, and disease pathogenesis (HIV/SLE)
  • Clinical/translational research (HIV/SLE)
  • I01 CX002422 Jiang (PI) 2/28/2022-2/27/2026 VA CSRD Merit Investigate the mechanism of autoreactive B cell-mediated immunological failure despite virologic suppression in HIV-infected individuals on antiretroviral therapy. 5R01 AI128864 Jiang (PI) 05/01/17-4/30/22 NIH/NIAID On the pathogenic role of anti-CD4 antibody in poor CD4+ T cell recovery after antiretroviral therapy in HIV disease
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1. Luo Z, Wu Yx, Meng Z, Martin L, Zhang L, Ogunrinde E, Zhou Z, Qin S, Wan Z, Westerink M, Warth S, Liu H, Jin P, Stroncek D, Li QZ, Wang E, Wu X, Heath S, LiZ, Alekseyenko A, JiangW*. Systemictranslocation of Staphylococcus drives autoantibody production in HIV disease. Microbiome. 2019. Feb 14;7(1):25. doi: 10.1186/s40168-019-0646-1. PMID: 30764863. *Awarded as the 2019 high impact research publication by the Dean, College of Medicine, Medical University of SouthCarolina.

2.Ogunrinde E, Zhou Z, Luo Z, Alekseyenko A, Li QZ, Macedo D, Kamen DL, Oates JC, Gilkeson GS, Jiang W*. A link between plasma microbial translocation, microbiome, and autoantibody development in first- degree relatives of systemic lupus erythematosus patients. Arthritis & Rheumatology. 2019. May 20. doi: 10.1002/art.40935.PMID:31106972

3. Luo Z, Fitting S, Robinson C, Benitez A, Li M, Wu Y, Fu X, Amato D, Ning W, Funderburg N, Wang X, Yu X, Wagner A, Cong X, Xu W, Maas K, McRae-Clark A, Hamlett E*, Jiang W*. Chronic cannabis smoking-enriched oral pathobiont drives behavioral changes and increases β-amyloid protein production in the brain. EbioMedicine. 2021 Nov 23;74:103701. doi:10.1016/j.ebiom.2021.103701. PMID: 34826801, PMCID: PMC8626580

4.  Luo Z, Health SL, Li M, Yang H, Wu Y, Collins M, Deeks SG, Martin JN, Scott A*, Jiang W*. Variation in blood microbial lipopolysaccharide (LPS) contributes to immune reconstitution in response to suppressive antiretroviral therapy in HIV. EbioMedicine. 2022 Apr 29;80:104037. doi: 10.1016/j.ebiom.2022.104037. PMID:35500539

5. Fu X, Cheng D, Luo Z, Wagner A, Fitting S, Cong X, Xu W, Maas K, Wan Z, Zhu J, Zhou Z, Stoops W, McRae-Clark A, Jiang W*. Oral enrichment of Streptococcus and its role in systemic inflammation related to monocyte activation in humans with cocaine use disorder. Journal of Neuroimmune Pharmacology2021 Aug 26. doi: 10.1007/s11481-021-10007-6.PMID: 34448131