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Oleg Palygin PhD

SmartState MUSC Renal Disease Biomarkers Endowed Chair

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  • Associate Professor
  • College of Medicine
  • Medicine
Academic Focus
  • Glomerulus in health and disease.
  • Pathophysiology of cardiorenal syndrome.
  • Renal channelopathies.
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I obtained my Ph.D. in biophysics at the Bogomoletz Institute of Physiology in Kyiv, Ukraine. Following the completion of my graduate work, I had postdoctoral training in USA and UK. After the end of my postdoctoral terms at University of Iowa and University of Warwick, I joined Physiology Department at the Medical College of Wisconsin and was promoted to Assistant Professor in 2014. I continue my career at the Division of Nephrology, Department of Medicine, Medical University of South Carolina where I have been promoted to Associate Professor in 2021. My extensive training and skills gave me the ability to answer scientific questions from all angles and helped me in the development of my own line of research. Technically, I am an expert in multiple methods, including patch-clamp electrophysiology, confocal and multiphoton microscopy, intravital and scanning ion-conductance imaging, biosensor amperometry, vibrodissociation, and its applications for the studies of various signaling mechanisms in the brain and kidney.

My research is focused on ion channels and ion transport in the kidney, and I apply multiple sophisticated approaches to address unresolved questions of physiological mechanisms responsible for the regulation of renal function in health and disease. The capacity of the human kidney to control and regulate cardiovascular health is enormous and has been implicated in many of the physiological factors associated with the general health status. Today, a greater understanding has been achieved of the cellular and molecular mechanisms underlying the processes of renal function, and how these processes may become disordered in chronic kidney disease states such as hypertension, polycystic kidney and diabetes mellitus. My laboratory is interested in several aspects of the kidney: its ability to control and regulate body electrolytes, its vulnerability to genetically related mutations, oxidative stress, albuminuria, and the role that transport potassium channels, protease-activated receptors and the purines like ATP play in these processes. The objective of my active NIH-supported research is to determine the mechanisms controlling expression and activity of the inwardly rectifying K+ channels (Kir) in the kidney.