Xuezhong Yu MD, MS
Endowed Chair, S.C. SmartState Endowed Chair in Cancer Stem Cell Biology and Therapy
843-792-4756
yux@musc.edu
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Biography
The research in Dr. Yu’s Lab focuses on the biology of graft-versus-host
disease (GVHD) and graft-versus-leukemia (GVL) after allogeneic
hematopoietic stem cell transplantation (HSCT). The ultimate goal of
these studies is to prevent or treat GVHD while preserving GVL effect,
which could greatly enhance the therapeutic potential of HSCT. Because T
cells play central role to induce GVHD and mediated GVL effect,
understanding T-cell response to normal tissue versus tumor cells is
critical for achieving the ultimate goal. The major lines of current
work in Dr. Yu’s Lab include: 1) T-cell differentiation and GVHD
development; 2) Biology of regulatory T cells and their potential
application in the control of GVHD; 3) Understanding how micro-RNAs
regulate T- and B-cell responses after allogeneic HSCT; 4) Evaluation of
metabolic pathways or intermediates as biomarkers and therapeutic
targets in GVHD and leukemia relapse.
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