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Russell Spencer-Smith PhD

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Rank
  • Assistant Professor
College
  • College of Medicine
Department
  • Cell and Molecular Pharmacology and Experimental Therapeutics
Academic Focus
  • Uncover novel drug targets in RAS-driven cancers
  • Develop assays to study RAS-MAPK pathway signaling in live cells
  • Improve therapeutic guidance for RASopathy patients
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Biography

I received my PhD in Molecular Pharmacology from the University of Illinois College of Medicine in 2017. I then completed my postdoctoral training at the National Cancer Institute, before accepting a faculty position in the MUSC Department of Cell and Molecular Pharmacology and Experimental Therapeutics in 2023. The RAS-MAPK pathway is hyperactivated in 30-40% of human cancers; however, there remains a dearth of effective drugs that target this pathway. The primary objective of our lab is to uncover new vulnerabilities in RAS-MAPK signaling through the study of rare disease-associated mutations therein.